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Jessica A Willi

Explore the profile of Jessica A Willi including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Alejo J, Girodat D, Hammerling M, Willi J, Jewett M, Engelhart A, et al.
PLoS Comput Biol . 2024 Aug; 20(8):e1012319. PMID: 39141679
Translocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation. An essential conformational change during this process is the...
2.
Willi J, Karim A, Jewett M
ACS Synth Biol . 2024 Jul; 13(7):2253-2259. PMID: 38979618
Cell-free gene expression systems are used in numerous applications, including medicine making, diagnostics, and educational kits. Accurate quantification of nonfluorescent proteins in these systems remains a challenge. To address this...
3.
Kofman C, Willi J, Karim A, Jewett M
ACS Cent Sci . 2024 Apr; 10(4):871-881. PMID: 38680563
The biosynthetic capability of the bacterial ribosome motivates efforts to understand and harness sequence-optimized versions for synthetic biology. However, functional differences between natively occurring ribosomal RNA (rRNA) operon sequences remain...
4.
Lee K, Willi J, Cho N, Kim I, Jewett M, Lee J
Biotechnol Bioprocess Eng . 2023 Feb; :1-17. PMID: 36778039
A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic...
5.
Kofman C, Watkins A, Kim D, Willi J, Wooldredge A, Karim A, et al.
Nucleic Acids Res . 2022 Dec; 50(22):13143-13154. PMID: 36484094
Understanding how modifications to the ribosome affect function has implications for studying ribosome biogenesis, building minimal cells, and repurposing ribosomes for synthetic biology. However, efforts to design sequence-modified ribosomes have...