Jessica A Neal
Overview
Explore the profile of Jessica A Neal including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
469
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0
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Recent Articles
1.
Neal J, Dunger K, Geith K, Meek K
DNA Repair (Amst)
. 2020 Jul;
94:102925.
PMID: 32674014
It has recently been established that the marked sensitivity of ATM deficient cells to topoisomerase poisons like camptothecin (Cpt) results from unrestrained end-joining of DNA ends at collapsed replication forks...
2.
Neal J, Meek K
DNA Repair (Amst)
. 2018 Nov;
73:7-16.
PMID: 30409670
DNA-PKcs deficiency has been studied in numerous animal models and cell culture systems. In previous studies of kinase inactivating mutations in cell culture systems, ablation of DNA-PK's catalytic activity results...
3.
Meek K, Xu Y, Bailie C, Yu K, Neal J
J Immunol
. 2016 Aug;
197(8):3165-3174.
PMID: 27574300
The evidence that ATM affects resolution of RAG-induced DNA double-strand breaks is profuse and unequivocal; moreover, it is clear that the RAG complex itself cooperates (in an undetermined way) with...
4.
Neal J, Xu Y, Abe M, Hendrickson E, Meek K
J Immunol
. 2016 Feb;
196(7):3032-42.
PMID: 26921311
Unlike most DNA-dependent protein kinase, catalytic subunit (DNA-PKcs)-deficient mouse cell strains, we show in the present study that targeted deletion of DNA-PKcs in two different human cell lines abrogates VDJ...
5.
Ying S, Chen Z, Medhurst A, Neal J, Bao Z, Mortusewicz O, et al.
Cancer Res
. 2015 Nov;
76(5):1078-88.
PMID: 26603896
A series of critical pathways are responsible for the detection, signaling, and restart of replication forks that encounter blocks during S-phase progression. Small base lesions may obstruct replication fork progression...
6.
Douglas P, Ye R, Trinkle-Mulcahy L, Neal J, De Wever V, Morrice N, et al.
Biosci Rep
. 2014 May;
34(3).
PMID: 24844881
The protein kinase activity of the DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and its autophosphorylation are critical for DBS (DNA double-strand break) repair via NHEJ (non-homologous end-joining). Recent studies have...
7.
Neal J, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller S, et al.
Mol Cell Biol
. 2014 Apr;
34(12):2162-75.
PMID: 24687855
DNA-dependent protein kinase (DNA-PK) orchestrates DNA repair by regulating access to breaks through autophosphorylations within two clusters of sites (ABCDE and PQR). Blocking ABCDE phosphorylation (by alanine mutation) imparts a...
8.
Woodbine L, Neal J, Sasi N, Shimada M, Deem K, Coleman H, et al.
J Clin Invest
. 2013 Jun;
123(7):2969-80.
PMID: 23722905
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ), the major DNA double strand break (DSB) rejoining pathway. NHEJ also functions during lymphocyte...
9.
Roy S, Andres S, Vergnes A, Neal J, Xu Y, Yu Y, et al.
Nucleic Acids Res
. 2012 Jan;
40(4):1684-94.
PMID: 22228831
XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4...
10.
Neal J, Meek K
Mutat Res
. 2011 Mar;
711(1-2):73-86.
PMID: 21376743
DNA double-strand breaks are extremely harmful lesions that can lead to genomic instability and cell death if not properly repaired. There are at least three pathways that are responsible for...