Jerzy Samolej
Overview
Explore the profile of Jerzy Samolej including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
73
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Recent Articles
1.
Krause M, Samolej J, Yakimovich A, Kriston-Vizi J, Huttunen M, Lara-Reyna S, et al.
J Cell Biol
. 2024 May;
223(6).
PMID: 38709216
Autophagy is an essential degradation program required for cell homeostasis. Among its functions is the engulfment and destruction of cytosolic pathogens, termed xenophagy. Not surprisingly, many pathogens use various strategies...
2.
Samolej J, White I, Strang B, Mercer J
J Gen Virol
. 2024 Mar;
105(3).
PMID: 38546099
Cardiac glycosides (CGs) are natural steroid glycosides, which act as inhibitors of the cellular sodium-potassium ATPase pump. Although traditionally considered toxic to human cells, CGs are widely used as drugs...
3.
Samolej J, Mendonca D, Upfold N, McElwee M, Landsberger M, Yakimovich A, et al.
Microbiol Spectr
. 2024 Feb;
12(4):e0407223.
PMID: 38376353
We previously identified the bisbenzimide Hoechst 33342 (H42) as a potent multi-stage inhibitor of the prototypic poxvirus, the vaccinia virus (VACV), and several parapoxviruses. A recent report showed that novel...
4.
Bidgood S, Samolej J, Novy K, Collopy A, Albrecht D, Krause M, et al.
PLoS Pathog
. 2022 Jul;
18(7):e1010614.
PMID: 35834477
All poxviruses contain a set of proteinaceous structures termed lateral bodies (LB) that deliver viral effector proteins into the host cytosol during virus entry. To date, the spatial proteotype of...
5.
Wise E, Samolej J, Elliott G
J Virol
. 2022 Jun;
96(14):e0192621.
PMID: 35758691
Virion host shutoff (vhs) protein is an endoribonuclease encoded by herpes simplex virus 1 (HSV1). vhs causes several changes to the infected cell environment that favor the translation of late...
6.
Martin C, Samolej J, Olson A, Bertoli C, Wiebe M, de Bruin R, et al.
Viruses
. 2022 Feb;
14(2).
PMID: 35216024
Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to...
7.
Huttunen M, Samolej J, Evans R, Yakimovich A, White I, Kriston-Vizi J, et al.
Life Sci Alliance
. 2021 Jun;
4(8).
PMID: 34145027
Poxvirus egress is a complex process whereby cytoplasmic single membrane-bound virions are wrapped in a cell-derived double membrane. These triple-membrane particles, termed intracellular enveloped virions (IEVs), are released from infected...
8.
Russell T, Samolej J, Hollinshead M, Smith G, Kite J, Elliott G
mBio
. 2021 May;
12(3).
PMID: 33975940
Enveloped viruses exploit cellular trafficking pathways for their morphogenesis, providing potential scope for the development of new antiviral therapies. We have previously shown that herpes simplex virus 1 (HSV1) utilizes...
9.
Wood J, White I, Samolej J, Mercer J
Cell Microbiol
. 2021 Apr;
23(8):e13334.
PMID: 33792166
The replication and assembly of vaccinia virus (VACV), the prototypic poxvirus, occurs exclusively in the cytoplasm of host cells. While the role of cellular cytoskeletal components in these processes remains...
10.
Yakimovich A, Huttunen M, Samolej J, Clough B, Yoshida N, Mostowy S, et al.
mSphere
. 2020 Sep;
5(5).
PMID: 32907956
The use of deep neural networks (DNNs) for analysis of complex biomedical images shows great promise but is hampered by a lack of large verified data sets for rapid network...