Jerry Fowler
Overview
Explore the profile of Jerry Fowler including associated specialties, affiliations and a list of published articles.
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20
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716
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Recent Articles
1.
Yu Y, Chang K, Chen J, Bohlender R, Fowler J, Zhang D, et al.
HGG Adv
. 2022 Jan;
3(1):100078.
PMID: 35047863
Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a...
2.
Ozcan Z, San Lucas F, Wong J, Chang K, Stopsack K, Fowler J, et al.
Bioinformatics
. 2022 Jan;
38(6):1483-1490.
PMID: 34999743
Motivation: RNA-sequencing (RNA-seq) of tumor tissue is typically only used to measure gene expression. Here, we present a statistical approach that leverages existing RNA-seq data to also detect somatic copy...
3.
Sivakumar S, San Lucas F, Jakubek Y, Ozcan Z, Fowler J, Scheet P
Genetics
. 2021 Mar;
217(1):1-12.
PMID: 33683368
Somatic copy number alterations (SCNAs) serve as hallmarks of tumorigenesis and often result in deviations from one-to-one allelic ratios at heterozygous loci, leading to allelic imbalance (AI). The Cancer Genome...
4.
Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung
Sivakumar S, San Lucas F, Jakubek Y, McDowell T, Lang W, Kallsen N, et al.
EBioMedicine
. 2019 Mar;
42:296-303.
PMID: 30905849
Background: Genomic investigation of atypical adenomatous hyperplasia (AAH), the only known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the low mutant cell fractions. This necessitates sensitive methods...
5.
Kadara H, Sivakumar S, Jakubek Y, San Lucas F, Lang W, McDowell T, et al.
Am J Respir Crit Care Med
. 2019 Mar;
200(6):742-750.
PMID: 30896962
Uninvolved normal-appearing airway epithelium has been shown to exhibit specific mutations characteristic of nearby non-small cell lung cancers (NSCLCs). Yet, its somatic mutational landscape in patients with early-stage NSCLC is...
6.
Fowler J, San Lucas F, Scheet P
Genet Epidemiol
. 2018 Dec;
43(2):227-237.
PMID: 30565316
The reproducibility of scientific processes is one of the paramount problems of bioinformatics, an engineering problem that must be addressed to perform good research. The System for Quality-Assured Data Analysis...
7.
Liu Y, Weber Z, San Lucas F, Deshpande A, Jakubek Y, Sulaiman R, et al.
Gynecol Oncol
. 2018 Sep;
151(2):243-249.
PMID: 30194005
Objective: Uterine carcinosarcoma (UCS) is a rare and aggressive form of uterine cancer. It is bi-phasic, exhibiting histological features of both malignant epithelial (carcinoma) and mesenchymal (sarcoma) elements, reflected in...
8.
Hoffman K, Hutchinson D, Fowler J, Smith D, Ajami N, Zhao H, et al.
PLoS One
. 2018 Apr;
13(4):e0194100.
PMID: 29694348
The oral microbiome has been linked to a number of chronic inflammatory conditions, including obesity, diabetes, periodontitis, and cancers of the stomach and liver. These conditions disproportionately affect Mexican American...
9.
Yu Y, Hu H, Chen J, Hu F, Fowler J, Scheet P, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Jan;
1864(6 Pt B):2247-2254.
PMID: 29317335
While a number of genes have been implicated in melanoma susceptibility, the role of protein-coding variation in melanoma development and progression remains underexplored. To better characterize the role of germline...
10.
Deshpande A, Lang W, McDowell T, Sivakumar S, Zhang J, Wang J, et al.
BMC Bioinformatics
. 2018 Jan;
19(1):5.
PMID: 29301485
Background: 'Next-generation' (NGS) sequencing has wide application in medical genetics, including the detection of somatic variation in cancer. The Ion Torrent-based (IONT) platform is among NGS technologies employed in clinical,...