Jeroen R Huyghe
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Explore the profile of Jeroen R Huyghe including associated specialties, affiliations and a list of published articles.
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88
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3513
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Recent Articles
11.
Tian Y, Lin Y, Qu C, Arndt V, Baurley J, Berndt S, et al.
Br J Cancer
. 2024 Apr;
130(10):1687-1696.
PMID: 38561434
Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT...
12.
Papadimitriou N, Qu C, Harrison T, Bever A, Martin R, Tsilidis K, et al.
EBioMedicine
. 2024 Feb;
101:105010.
PMID: 38350331
Background: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. Methods: We used Mendelian randomization...
13.
Thomas C, Georgeson P, Qu C, Steinfelder R, Buchanan D, Song M, et al.
Cancer Epidemiol Biomarkers Prev
. 2024 Jan;
33(4):534-546.
PMID: 38252034
Background: The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88. Methods:...
14.
Bull C, Hazelwood E, Bell J, Tan V, Constantinescu A, Borges C, et al.
Elife
. 2023 Dec;
12.
PMID: 38127078
Background: Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival. Methods: To investigate whether changes in circulating metabolites characterize the early stages of...
15.
Stern M, Sanchez Mendez J, Kim A, Obon-Santacana M, Moratalla-Navarro F, Martin V, et al.
Cancer Epidemiol Biomarkers Prev
. 2023 Dec;
33(3):400-410.
PMID: 38112776
Background: High red meat and/or processed meat consumption are established colorectal cancer risk factors. We conducted a genome-wide gene-environment (GxE) interaction analysis to identify genetic variants that may modify these...
16.
Thomas M, Su Y, Rosenthal E, Sakoda L, Schmit S, Timofeeva M, et al.
Nat Commun
. 2023 Oct;
14(1):6147.
PMID: 37783704
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry...
17.
Bouras E, Kim A, Lin Y, Morrison J, Du M, Albanes D, et al.
Am J Clin Nutr
. 2023 Aug;
118(5):881-891.
PMID: 37640106
Background: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation...
18.
Chen Z, Song W, Shu X, Wen W, Devall M, Dampier C, et al.
J Natl Cancer Inst
. 2023 Aug;
116(1):127-137.
PMID: 37632791
Background: Transcriptome-wide association studies have been successful in identifying candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene discovery, we conducted a large transcriptome-wide association study and an...
19.
Constantinescu A, Bull C, Jones N, Mitchell R, Burrows K, Dimou N, et al.
Int J Cancer
. 2023 Aug;
154(1):94-103.
PMID: 37578112
Observational studies have suggested a protective role for eosinophils in colorectal cancer (CRC) development and implicated neutrophils, but the causal relationships remain unclear. Here, we aimed to estimate the causal...
20.
Dimou N, Kim A, Flanagan O, Murphy N, Diez-Obrero V, Shcherbina A, et al.
Br J Cancer
. 2023 Jun;
129(3):511-520.
PMID: 37365285
Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by...