Jeremy Thompson
Overview
Explore the profile of Jeremy Thompson including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
698
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0
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Recent Articles
11.
Chen Q, Thompson J, Hu Y, Lesnefsky E
Am J Physiol Cell Physiol
. 2022 Jan;
322(2):C296-C310.
PMID: 35044856
Aging chronically increases endoplasmic reticulum (ER) stress that contributes to mitochondrial dysfunction. Activation of calpain 1 (CPN1) impairs mitochondrial function during acute ER stress. We proposed that aging-induced ER stress...
12.
Tang J, Delmiglio C, Ward L, Thompson J
Arch Virol
. 2022 Jan;
167(2):651-654.
PMID: 35043228
A novel virus, tentatively named "sweetbriar rose curly-top associated virus" (SRCTaV), was identified in sweetbriar rose (Rosa rubiginosa) using high-throughput sequencing. The complete genome sequence of SRCTaV was determined and...
13.
Li L, Thompson J, Hu Y, Lesnefsky E, Willard B, Chen Q
Sci Rep
. 2022 Jan;
12(1):138.
PMID: 34997008
Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury during ischemia (ISC)-reperfusion (REP) by improving mitochondrial function....
14.
Chen Q, Thompson J, Hu Y, Lesnefsky E
Aging (Albany NY)
. 2021 Mar;
13(6):7828-7845.
PMID: 33746115
Aging impairs mitochondrial function that leads to greater cardiac injury during ischemia and reperfusion. Cardiac endoplasm reticulum (ER) stress increases with age and contributes to mitochondrial dysfunction. Metformin is an...
15.
Thompson J, Maceyka M, Chen Q
Mech Ageing Dev
. 2020 Oct;
192:111380.
PMID: 33045249
Severity of cardiovascular disease increases markedly in elderly patients. In addition, many therapeutic strategies that decrease cardiac injury in adult patients are invalid in elderly patients. Thus, it is a...
16.
Chen Q, Thompson J, Hu Y, Lesnefsky E
Free Radic Biol Med
. 2020 Jul;
158:162-170.
PMID: 32711023
p53 is a tumor suppressor protein with a very low content in the basal condition, but the content rapidly rises during stress conditions including ischemia-reperfusion. An increase in p53 content...
17.
Gertz Z, Cain C, Kraskauskas D, Devarakonda T, Mauro A, Thompson J, et al.
JACC CardioOncol
. 2020 Jul;
1(2):221-234.
PMID: 32699841
Objectives: Because of its multifaceted cardioprotective effects, remote ischemic pre-conditioning (RIPC) was examined as a strategy to attenuate doxorubicin (DOX) cardiotoxicity. Background: The use of DOX is limited by dose-dependent...
18.
Chen Q, Samidurai A, Thompson J, Hu Y, Das A, Willard B, et al.
Biochim Biophys Acta Mol Basis Dis
. 2020 Jul;
1866(11):165899.
PMID: 32698045
Aging impairs the mitochondrial electron transport chain (ETC), especially in interfibrillar mitochondria (IFM). Mitochondria are in close contact with the endoplasmic reticulum (ER). Induction of ER stress leads to ETC...
19.
Mohsin A, Thompson J, Hu Y, Hollander J, Lesnefsky E, Chen Q
Arch Biochem Biophys
. 2020 Feb;
683:108299.
PMID: 32061585
Background: ER (endoplasmic reticulum) stress leads to decreased complex I activity in cardiac mitochondria. The aim of the current study is to explore the potential mechanisms by which ER stress...
20.
Chen Q, Thompson J, Hu Y, Dean J, Lesnefsky E
Am J Physiol Cell Physiol
. 2019 Aug;
317(5):C910-C921.
PMID: 31411917
Activation of calpain 1 (CPN1) and calpain 2 (CPN2) contributes to cardiac injury during ischemia (ISC) and reperfusion (REP). Complex I activity is decreased in heart mitochondria following ISC-REP. CPN1...