Jeremy Smedley
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Explore the profile of Jeremy Smedley including associated specialties, affiliations and a list of published articles.
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64
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1553
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Recent Articles
1.
Shapiro M, Ordonez T, Pandey S, Mahyari E, Onwuzu K, Reed J, et al.
JCI Insight
. 2024 Aug;
9(19).
PMID: 39190496
Transmission of HIV-1 to newborns and infants remains high, with 130,000 new infections in 2022 in resource-limited settings. Half of HIV-infected newborns, if untreated, progress to disease and death within...
2.
Webb G, Pessoa C, McCullen A, Hwang J, Humkey M, Thormin-Odum R, et al.
J Virol
. 2024 May;
98(6):e0027324.
PMID: 38775481
TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. TIGIT upregulation in virus-specific CD8 T cells and NK cells during HIV/SIV infection results...
3.
Keele B, Okoye A, Fennessey C, Varco-Merth B, Immonen T, Kose E, et al.
PLoS Pathog
. 2024 Apr;
20(4):e1012135.
PMID: 38593120
The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time...
4.
5.
Smedley J, Turkbey B, Bernardo M, Del Prete G, Estes J, Griffiths G, et al.
PLoS One
. 2023 Jul;
18(7):e0288566.
PMID: 37418480
[This corrects the article DOI: 10.1371/journal.pone.0092830.].
6.
Ricciardi M, Rust L, Pedreno-Lopez N, Yusova S, Biswas S, Webb G, et al.
Sci Transl Med
. 2023 Mar;
15(689):eade5795.
PMID: 36989376
Yellow fever virus (YFV) is a reemerging global health threat, driven by several factors, including increased spread of the mosquito vector and rapid urbanization. Although a prophylactic vaccine exists, vaccine...
7.
Lavinder T, Fachko D, Stanton J, Varco-Merth B, Smedley J, Okoye A, et al.
Comp Med
. 2022 Sep;
72(5):287-297.
PMID: 36162961
HIV-infected people develop reproducible disruptions in their gastrointestinal microbiota. Despite the suppression of HIV viremia via long-term antiretroviral therapy (ART), alterations still occur in gut microbial diversity and the commensal...
8.
Malouli D, Gilbride R, Wu H, Hwang J, Maier N, Hughes C, et al.
Cell Host Microbe
. 2022 Aug;
30(9):1207-1218.e7.
PMID: 35981532
Strain 68-1 rhesus cytomegalovirus expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in 50%-60% of the vaccinated rhesus macaques. Whether this unconventional...
9.
Hansen S, Hancock M, Malouli D, Marshall E, Hughes C, Randall K, et al.
Sci Immunol
. 2022 Jun;
7(72):eabn9301.
PMID: 35714200
The strain 68-1 rhesus cytomegalovirus (RhCMV)-based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This...
10.
Chang X, Reed J, Webb G, Wu H, Le J, Bateman K, et al.
PLoS Pathog
. 2022 Mar;
18(3):e1010396.
PMID: 35358290
The CCR5-specific antibody Leronlimab is being investigated as a novel immunotherapy that can suppress HIV replication with minimal side effects. Here we studied the virological and immunological consequences of Leronlimab...