Jeremy Saklatvala
Overview
Explore the profile of Jeremy Saklatvala including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
51
Citations
2357
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Asopa V, Vincent T, Saklatvala J
Biomed Res Int
. 2020 May;
2020:4060135.
PMID: 32461985
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage. The age-related difference in collagen II synthesis is poorly understood. This is the first systematic investigation...
2.
Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, et al.
Ann Rheum Dis
. 2018 Jun;
77(9):1372-1380.
PMID: 29925506
Objectives: One mechanism by which cartilage responds to mechanical load is by releasing heparin-bound growth factors from the pericellular matrix (PCM). By proteomic analysis of the PCM, we identified connective...
3.
Ismail H, Didangelos A, Vincent T, Saklatvala J
Arthritis Rheumatol
. 2016 Oct;
69(3):565-575.
PMID: 27768832
Objective: Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding of the articular cartilage surface causes rapid activation of MAP kinases and NF-κB, mimicking the response to inflammatory cytokines. This...
4.
Watt F, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, et al.
Arthritis Rheumatol
. 2016 Mar;
68(9):2129-40.
PMID: 26991527
Objective: To investigate whether molecules found to be up-regulated within hours of surgical joint destabilization in the mouse are also elevated in the analogous human setting of acute knee injury,...
5.
Ismail H, Miotla-Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, et al.
Arthritis Rheumatol
. 2015 Dec;
68(5):1165-71.
PMID: 26663140
Objective: The pathogenesis of osteoarthritis (OA) is poorly understood. Loss of the proteoglycan aggrecan from cartilage is an early event. Recently, we identified a role for the JNK pathway, particularly...
6.
Smallie T, Ross E, Ammit A, Cunliffe H, Tang T, Rosner D, et al.
J Immunol
. 2015 May;
195(1):277-88.
PMID: 26019272
Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses,...
7.
Ross E, Smallie T, Ding Q, ONeil J, Cunliffe H, Tang T, et al.
J Immunol
. 2015 May;
195(1):265-76.
PMID: 26002976
In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178,...
8.
Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J
Arthritis Rheumatol
. 2015 Mar;
67(7):1826-36.
PMID: 25776267
Objective: Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytokines such as interleukin-1...
9.
Lo Cascio L, Liu K, Nakamura H, Chu G, Lim N, Chanalaris A, et al.
Genesis
. 2013 Dec;
52(2):110-9.
PMID: 24339176
We have used an aggrecan gene enhancer to generate a transgenic murine line (Acan-CreER-Ires-Luc) expressing firefly luciferase and tamoxifen activatable Cre recombinase (Cre-ER(T2) ). The expression and efficiency of the...
10.
Crowe J, Aubareda A, McNamee K, Przybycien P, Lu X, Williams R, et al.
PLoS One
. 2013 Oct;
8(10):e77383.
PMID: 24143227
There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice overexpressing human hspB1 protein....