Jeremy M Sivak
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Explore the profile of Jeremy M Sivak including associated specialties, affiliations and a list of published articles.
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39
Citations
872
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Recent Articles
1.
Dang M, Slaughter K, Cui H, Jiang C, Zhou L, Matthew D, et al.
Adv Mater
. 2025 Jan;
37(8):e2419306.
PMID: 39763100
Colloidal drug aggregates (CDAs) are challenging in drug discovery due to their unpredictable formation and interference with screening assays. These limitations are turned into a strategic advantage by leveraging CDAs...
2.
Chan D, Zhang J, Won G, Sivak J
Acta Neuropathol Commun
. 2024 Nov;
12(1):186.
PMID: 39616406
Pathobiology of the intact human retina has been challenging to study due to its relative inaccessibility and limited sample availability. Thus, there is a great need for new translational models...
3.
Liu H, Cullen P, Sivak J, Gronert K, Flanagan J
bioRxiv
. 2024 Jan;
PMID: 38293224
Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the retinal nerve fiber layer (RNFL), resulting in a gradual decline of vision. A...
4.
Aubry A, Pearson J, Charish J, Yu T, Sivak J, Xirodimas D, et al.
Cell Rep
. 2024 Jan;
43(2):113711.
PMID: 38236775
No abstract available.
5.
Livne-Bar I, Maurya S, Gronert K, Sivak J
J Neuroinflammation
. 2024 Jan;
21(1):18.
PMID: 38212822
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A and B (LXA and LXB) have...
6.
Aubry A, Pearson J, Charish J, Yu T, Sivak J, Xirodimas D, et al.
Cell Rep
. 2023 Aug;
42(8):112925.
PMID: 37552601
The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers. Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of non-CRL targets is unknown. Here,...
7.
Vicic N, Guo X, Chan D, Flanagan J, Sigal I, Sivak J
J Cell Physiol
. 2022 Jul;
237(9):3687-3702.
PMID: 35862065
Glaucoma is a common neurodegenerative blinding disease that is closely associated with chronic biomechanical strain at the optic nerve head (ONH). Yet, the cellular injury and mechanosensing mechanisms underlying the...
8.
Frank Lee C, Brown C, Nielsen A, Kim C, Livne-Bar I, Parsons P, et al.
Chemistry
. 2022 May;
28(35):e202200360.
PMID: 35491534
Two stereocontrolled, efficient, and modular syntheses of eicosanoid lipoxin B4 (LXB ) are reported. One features a stereoselective reduction followed by an asymmetric epoxidation sequence to set the vicinal diol...
9.
Mathew D, Livne-Bar I, Sivak J
Sci Rep
. 2021 Nov;
11(1):22880.
PMID: 34819548
Glaucoma is a chronic and progressive neurodegenerative disease of the optic nerve resulting in loss of retinal ganglion cells (RGCs) and vision. The most prominent glaucoma risk factor is increased...
10.
Alqawlaq S, Livne-Bar I, Williams D, DErcole J, Leung S, Chan D, et al.
J Biol Chem
. 2020 Nov;
296:100118.
PMID: 33234594
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, analyzing the effects of the astrocyte secretome may provide...