Jeremy A Simpson
Overview
Explore the profile of Jeremy A Simpson including associated specialties, affiliations and a list of published articles.
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67
Citations
979
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Recent Articles
1.
Wearing O, Chesler N, Colebank M, Hacker T, Lorenz J, Simpson J, et al.
Am J Physiol Heart Circ Physiol
. 2024 Dec;
328(1):H120-H140.
PMID: 39625460
Ventricular catheterization with a pressure-volume (PV) catheter is the gold-standard method for assessing in vivo cardiac function in animal studies, providing valuable "load-independent" indices of systolic and diastolic heart performance....
2.
Delfinis L, Khajehzadehshoushtar S, Flewwelling L, Andrews N, Garibotti M, Gandhi S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484418
Cancer cachexia, and the related loss of muscle and strength, worsens quality of life and lowers overall survival. Recently, a novel 'pre-atrophy' muscle weakness was identified during early-stage cancer. While...
3.
Nelson V, Eadie A, Perez L, Madhu M, Platt M, Mercer A, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456232
Myocardial infarction and reperfusion constitute a complex injury consisting of many distinct molecular stress patterns that influence cardiomyocyte survival and adaptation. Cell signalling, which is essential to cardiac development, also...
4.
Hughes M, Ramos S, Brahmbhatt A, Turnbull P, Polidovitch N, Garibotti M, et al.
Redox Biol
. 2024 Aug;
76:103319.
PMID: 39178732
Mitochondrial creatine kinase (mtCK) regulates the "fast" export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such "creatine-dependent" phosphate shuttling...
5.
Kleinbongard P, Senyo S, Lindsey M, Garvin A, Simpson J, de Castro Braz L
Am J Physiol Heart Circ Physiol
. 2024 Aug;
327(3):H681-H686.
PMID: 39093000
Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the myocardium, vasculature, and neuronal network and by contributing to...
6.
Ogilvie L, Delfinis L, Coyle-Asbil B, Vudatha V, Alshamali R, Garlisi B, et al.
Am J Pathol
. 2024 Jul;
194(10):1823-1843.
PMID: 39032600
Muscle atrophy and weakness are prevalent features of cancer. Although extensive research has characterized skeletal muscle wasting in cancer cachexia, limited studies have investigated how cardiac structure and function are...
7.
Marrow J, Alshamali R, Edgett B, Allwood M, Cochrane K, Al-Sabbag S, et al.
Front Physiol
. 2024 Jul;
15:1397049.
PMID: 39011088
Erythropoietin (EPO) exerts non-canonical roles beyond erythropoiesis that are developmentally, structurally, and physiologically relevant for the heart as a paracrine factor. The role for paracrine EPO signalling and cellular crosstalk...
8.
Delfinis L, Ogilvie L, Khajehzadehshoushtar S, Gandhi S, Garibotti M, Thuhan A, et al.
Mol Metab
. 2024 Jun;
86:101976.
PMID: 38925248
Objectives: A high proportion of women with advanced epithelial ovarian cancer (EOC) experience weakness and cachexia. This relationship is associated with increased morbidity and mortality. EOC is the most lethal...
9.
Eadie A, Simpson J, Brunt K
Pharmacol Res Perspect
. 2024 Jun;
12(4):e1225.
PMID: 38923404
Drug repurposing has gained significant interest in recent years due to the high costs associated with de novo drug development; however, comprehensive pharmacological information is needed for the translation of...
10.
Vishram-Nielsen J, Scolari F, Steve Fan C, Moayedi Y, Ross H, Manlhiot C, et al.
CJC Open
. 2024 Jun;
6(5):745-754.
PMID: 38846437
Background: Diaphragm atrophy can contribute to dyspnea in patients with heart failure (HF) with its link to central neurohormonal overactivation. HF medications that cross the blood-brain barrier could act centrally...