Jens Frey Halling
Overview
Explore the profile of Jens Frey Halling including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
468
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0
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Recent Articles
1.
Pham T, Raun S, Havula E, Henriquez-Olguin C, Rubalcava-Gracia D, Frank E, et al.
Nat Commun
. 2024 Nov;
15(1):9826.
PMID: 39537626
Decline in mitochondrial function is linked to decreased muscle mass and strength in conditions like sarcopenia and type 2 diabetes. Despite therapeutic opportunities, there is limited and equivocal data regarding...
2.
Christensen N, Ringholm S, Buch B, Gudiksen A, Halling J, Pilegaard H
Exp Gerontol
. 2022 Dec;
172:112046.
PMID: 36521568
Aging has been suggested to be associated with changes in oxidative capacity, autophagy, and mitophagy in the liver, but a simultaneous evaluation of these key cellular processes is lacking. Moreover,...
3.
Ringholm S, Gudiksen A, Halling J, Qoqaj A, Meizner Rasmussen P, Prats C, et al.
J Gerontol A Biol Sci Med Sci
. 2022 Aug;
78(3):373-383.
PMID: 35961318
Aging is associated with metabolic decline in skeletal muscle, which can be delayed by physical activity. Moreover, both lifelong and short-term exercise training have been shown to prevent age-associated fragmentation...
4.
Halling J, Pilegaard H
Appl Physiol Nutr Metab
. 2020 Jun;
45(9):927-936.
PMID: 32516539
The majority of human energy metabolism occurs in skeletal muscle mitochondria emphasizing the importance of understanding the regulation of myocellular mitochondrial function. The transcriptional co-activator peroxisome proliferator-activated receptor gamma coactivator...
5.
Buch B, Halling J, Ringholm S, Gudiksen A, Kjobsted R, Olsen M, et al.
FASEB J
. 2020 May;
34(6):8653-8670.
PMID: 32372536
The aim of the study was to investigate the impact of autophagy inhibition on skeletal muscle mitochondrial function and glucose homeostasis in young and aged mice. The transcriptional co-activator PGC-1α...
6.
Halling J, Jessen H, Nohr-Meldgaard J, Buch B, Christensen N, Gudiksen A, et al.
Am J Physiol Endocrinol Metab
. 2019 Jul;
317(3):E513-E525.
PMID: 31265325
Impaired mitochondrial function has been implicated in the pathogenesis of age-associated metabolic diseases through regulation of cellular redox balance. Exercise training is known to promote mitochondrial biogenesis in part through...
7.
Sailani M, Halling J, Moller H, Lee H, Plomgaard P, Pilegaard H, et al.
Sci Rep
. 2019 Mar;
9(1):3272.
PMID: 30824849
Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D), maintenance of muscle mass and increased metabolic capacity. However, little is known about epigenetic mechanisms that...
8.
Kjeld T, Stride N, Gudiksen A, Hansen E, Arendrup H, Horstmann P, et al.
PLoS One
. 2018 Sep;
13(9):e0201401.
PMID: 30231055
Background: The performance of elite breath hold divers (BHD) includes static breath hold for more than 11 minutes, swimming as far as 300 m, or going below 250 m in...
9.
Dethlefsen M, Halling J, Moller H, Plomgaard P, Regenberg B, Ringholm S, et al.
Exp Gerontol
. 2018 Jul;
111:141-153.
PMID: 30030137
Exercise training has been reported to prevent the age-induced decline in muscle mass and fragmentation of mitochondria, as well as to affect autophagy and mitophagy. The interaction between these pathways...
10.
Moller H, Mohiyuddin M, Prada-Luengo I, Sailani M, Halling J, Plomgaard P, et al.
Nat Commun
. 2018 Mar;
9(1):1069.
PMID: 29540679
The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected that...