Jennifer R Timoshanko
Overview
Explore the profile of Jennifer R Timoshanko including associated specialties, affiliations and a list of published articles.
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14
Citations
338
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Recent Articles
1.
Ruth A, Kitching A, Kwan R, Odobasic D, Ooi J, Timoshanko J, et al.
J Am Soc Nephrol
. 2006 Jun;
17(7):1940-9.
PMID: 16769746
Most humans with microscopic polyarteritis and anti-myeloperoxidase (anti-MPO), anti-neutrophil cytoplasmic antibodies (ANCA) develop "pauci-immune" crescentic glomerulonephritis. For dissection of the roles of ANCA and cell-mediated effectors in microscopic polyarteritis, experimental...
2.
Timoshanko J, Kitching A, Semple T, Tipping P, Holdsworth S
J Am Soc Nephrol
. 2005 Dec;
17(1):150-9.
PMID: 16319187
Mast cells infiltrate kidneys of humans with crescentic glomerulonephritis (GN), and the degree of infiltrate correlates with outcome. However, a functional role for mast cells in the pathogenesis of GN...
3.
Timoshanko J, Tipping P
Curr Drug Targets Inflamm Allergy
. 2005 Aug;
4(3):353-62.
PMID: 16101545
Each year, worldwide, there is an increasing number of patients with chronic kidney disease that progress to end-stage renal disease. Glomerulonephritis (GN) is the commonest single cause of end-stage renal...
4.
Timoshanko J, Kitching A, Semple T, Holdsworth S, Tipping P
J Am Soc Nephrol
. 2005 Jul;
16(9):2646-56.
PMID: 16033860
GM-CSF has previously been demonstrated to be important in crescentic glomerulonephritis (GN). As both renal parenchymal cells and infiltrating inflammatory cells produce GM-CSF, their separate contributions to inflammatory renal injury...
5.
Odobasic D, Kitching A, Semple T, Timoshanko J, Tipping P, Holdsworth S
J Am Soc Nephrol
. 2005 Jun;
16(7):2012-22.
PMID: 15944341
The participation of renal expression of CD80 and CD86 in the immunopathogenesis of crescentic Th1-mediated anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) has not been assessed. Immunohistochemical staining demonstrated prominent upregulation...
6.
Kitching A, Turner A, Wilson G, Semple T, Odobasic D, Timoshanko J, et al.
J Am Soc Nephrol
. 2005 May;
16(7):2023-33.
PMID: 15888563
Experimental crescentic glomerulonephritis (GN) is characterized by T helper 1 (Th1) directed nephritogenic immune responses and cell-mediated glomerular injury. IL-12p40, the common cytokine chain for both IL-12 and IL-23, is...
7.
Kitching A, Turner A, Semple T, Li M, Edgtton K, Wilson G, et al.
J Am Soc Nephrol
. 2004 Jun;
15(7):1764-74.
PMID: 15213264
IL-12 and IFN-gamma play key roles in murine lupus and planted antigen models of glomerulonephritis. However, their roles in renal organ-specific autoimmunity are unknown. To establish the roles of endogenous...
8.
Ruth A, Kitching A, Li M, Semple T, Timoshanko J, Tipping P, et al.
J Immunol
. 2004 Jun;
173(1):136-44.
PMID: 15210767
Crescentic glomerulonephritis (GN) results from IL-12-driven Th1-directed cell-mediated responses (akin to delayed-type hypersensitivity (DTH)) directed against glomerular Ags. CD40-CD154 interactions are critical for IL-12 production and Th1 polarization of immune...
9.
Timoshanko J, Kitching A, Iwakura Y, Holdsworth S, Tipping P
Am J Pathol
. 2004 May;
164(6):1967-77.
PMID: 15161633
The involvement of proinflammatory cytokines interleukin (IL)-1 and tumor necrosis factor (TNF) in crescentic glomerulonephritis (GN) is well established. Recently the requirement of intrinsic renal cell participation via their production...
10.
Timoshanko J, Kitching A, Iwakura Y, Holdsworth S, Tipping P
J Am Soc Nephrol
. 2004 Mar;
15(4):910-8.
PMID: 15034093
ABSTRACT. Interleukin-1 (IL-1) is a pleiotropic proinflammatory cytokine with two distinct isoforms (IL-1alpha and IL-1beta) that signal through the same IL-1 type I receptor (IL-1RI). Contributions of IL-1beta have been...