Jennifer N Uram
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Explore the profile of Jennifer N Uram including associated specialties, affiliations and a list of published articles.
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9
Citations
5453
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Recent Articles
1.
Le D, Uram J, Wang H, Bartlett B, Kemberling H, Eyring A, et al.
N Engl J Med
. 2015 Jun;
372(26):2509-20.
PMID: 26028255
Background: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with a large number of somatic mutations due to mismatch-repair defects may be susceptible to...
2.
Le D, Wang-Gillam A, Picozzi V, Greten T, Crocenzi T, Springett G, et al.
J Clin Oncol
. 2015 Jan;
33(12):1325-33.
PMID: 25584002
Purpose: GVAX pancreas, granulocyte-macrophage colony-stimulating factor-secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhibit regulatory T cells....
3.
Chen G, Gupta R, Petrik S, Laiko M, Leatherman J, Asquith J, et al.
Cancer Immunol Res
. 2014 Aug;
2(10):949-61.
PMID: 25116755
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccines are bioactive, but limited by disease burden and immune tolerance. Cyclophosphamide augments vaccine activity in tolerant neu mice and in patients with metastatic breast...
4.
Zheng L, Edil B, Soares K, El-Shami K, Uram J, Judkins C, et al.
Ann Surg Oncol
. 2014 Jun;
21(12):3931-7.
PMID: 24943235
Background: Despite recent advances in earlier detection and improvements in chemotherapy, the 5-year survival rate of patients with metastatic colorectal carcinoma remains poor. Immunotherapy is a potentially effective therapeutic approach...
5.
de Remigis A, de Gruijl T, Uram J, Tzou S, Iwama S, Talor M, et al.
Int J Cancer
. 2014 May;
136(1):127-37.
PMID: 24832153
Cancer immunotherapy induces a variety of autoinflammatory responses, including those against the thyroid gland, which can be exploited to predict clinical outcomes. Considering the paucity of information about thyroid autoimmunity...
6.
7.
Le D, Lutz E, Uram J, Sugar E, Onners B, Solt S, et al.
J Immunother
. 2013 Aug;
36(7):382-9.
PMID: 23924790
Preclinical reports support the concept of synergy between cancer vaccines and immune checkpoint blockade in nonimmunogenic tumors. In particular, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibodies have been successfully combined with...
8.
Uram J, Black C, Flynn E, Huang L, Armstrong T, Jaffee E
J Immunol
. 2011 Feb;
186(7):3847-57.
PMID: 21346233
We previously reported that CD8(+) T cells are directed predominantly toward the immunodominant Her-2/neu (neu) epitope RNEU(420-429) in nontolerized FVB/N but not tolerized HER-2/neu (neu-N) mice. In this study, we...
9.
Khush R, Cornwell W, Uram J, Lemaitre B
Curr Biol
. 2002 Oct;
12(20):1728-37.
PMID: 12401167
Background: The inducible production of antimicrobial peptides is a major immune response in Drosophila. The genes encoding these peptides are activated by NF-kappaB transcription factors that are controlled by two...