Jennifer N Kahn
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Explore the profile of Jennifer N Kahn including associated specialties, affiliations and a list of published articles.
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9
Citations
132
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Recent Articles
1.
Li X, Harijan R, Cao B, Kahn J, Pierce M, Tsymbal A, et al.
J Med Chem
. 2021 Oct;
64(20):15334-15348.
PMID: 34648707
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against ricin. We...
2.
Li X, Harijan R, Kahn J, Schramm V, Tumer N
ACS Infect Dis
. 2020 May;
6(7):1894-1905.
PMID: 32428396
Ricin toxin A subunit (RTA) removes an adenine from the universally conserved sarcin/ricin loop (SRL) on eukaryotic ribosomes, thereby inhibiting protein synthesis. No high affinity and selective small molecule therapeutic...
3.
Pierce M, Vengsarkar D, McLaughlin J, Kahn J, Tumer N
J Biol Chem
. 2019 Oct;
294(47):17848-17862.
PMID: 31624149
Ricin undergoes retrograde transport to the endoplasmic reticulum (ER), and ricin toxin A chain (RTA) enters the cytosol from the ER. Previous reports indicated that RTA inhibits activation of the...
4.
Zhou Y, Li X, Kahn J, McLaughlin J, Tumer N
Biosci Rep
. 2019 Sep;
39(10).
PMID: 31548364
Ricin interacts with the ribosomal P stalk to cleave a conserved adenine from the α-sarcin/ricin loop (SRL) of the rRNA. Ricin toxin A chain (RTA) uses Arg235 as the most...
5.
Li X, Kahn J, Tumer N
Toxins (Basel)
. 2018 Sep;
10(9).
PMID: 30217009
Ricin A chain (RTA) depurinates the sarcin/ricin loop (SRL) by interacting with the C-termini of the ribosomal P stalk. The ribosome interaction site and the active site are located on...
6.
Zhou Y, Li X, Kahn J, Tumer N
Toxins (Basel)
. 2018 Jun;
10(6).
PMID: 29899209
Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA. Direct assays for measuring depurination activity...
7.
McAllister K, Bouillaut L, Kahn J, Self W, Sorg J
Sci Rep
. 2017 Nov;
7(1):14672.
PMID: 29116155
Clostridium difficile is a significant concern as a nosocomial pathogen, and genetic tools are important when analyzing the physiology of such organisms so that the underlying physiology/pathogenesis of the organisms...
8.
Basu D, Kahn J, Li X, Tumer N
Infect Immun
. 2016 Sep;
84(12):3290-3301.
PMID: 27600507
The A1 subunits of Shiga toxin 1 (Stx1A1) and Shiga toxin 2 (Stx2A1) interact with the conserved C termini of ribosomal-stalk P-proteins to remove a specific adenine from the sarcin/ricin...
9.
Basu D, Li X, Kahn J, May K, Kahn P, Tumer N
Infect Immun
. 2015 Oct;
84(1):149-61.
PMID: 26483409
Shiga toxin (Stx)-producing Escherichia coli (STEC) infections can lead to life-threatening complications, including hemorrhagic colitis (HC) and hemolytic-uremic syndrome (HUS), which is the most common cause of acute renal failure...