Jennifer L Brooks
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Explore the profile of Jennifer L Brooks including associated specialties, affiliations and a list of published articles.
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8
Citations
81
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Recent Articles
1.
Tran J, Hartung J, Peach R, Boehm M, Rosen H, Smith H, et al.
J Clin Pharmacol
. 2017 Apr;
57(8):988-996.
PMID: 28398597
The sphingosine-1-phosphate 1 receptor (S1P ) is expressed by lymphocytes, dendritic cells, and vascular endothelial cells and plays a role in the regulation of chronic inflammation and lymphocyte egress from...
2.
Lewis G, Brooks J, Courtney H, Li Y, Haggard W
Clin Orthop Relat Res
. 2010 Mar;
468(8):2092-100.
PMID: 20195806
Background: When a physician-directed antibiotic-loaded polymethylmethacrylate (PMMA) bone cement (ALBC) formulation is used in total hip arthroplasties (THAs) and total knee arthroplasties (TKAs), current practice in the United States involves...
3.
Boyle N, Fagan P, Brooks J, Prhavc M, Lambert J, Cook P
Nucleosides Nucleotides Nucleic Acids
. 2006 Jan;
24(10-12):1651-64.
PMID: 16438041
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs which require three intracellular phosphorylation steps to yield their corresponding, biologically active, nucleoside triphosphate. In order to circumvent this often inefficient phosphorylation cascade,...
4.
Rajwanshi V, Prhavc M, Fagan P, Brooks J, Hurd T, Cook P, et al.
Nucleosides Nucleotides Nucleic Acids
. 2005 May;
24(3):179-89.
PMID: 15892257
3'-Azido-3',5-dideoxythymidine 5'-phosphonate and 3',5'-dideoxy-5'-difluoromethylenethymidine 5'-phosphonate were prepared by multistep syntheses. The nucleoside 5'-phosphonates were converted to their triphosphates and triphosphate mimics (P3Ms) containing beta,gamma-difluoromethylene, beta,gamma-dichloromethylene, or beta,gamma-imodo by condensation with...
5.
Boyle N, Rajwanshi V, Prhavc M, Wang G, Fagan P, Chen F, et al.
J Med Chem
. 2005 Apr;
48(7):2695-700.
PMID: 15801860
The triphosphates of antiviral 2',3'-dideoxynucleosides (ddNs) are the active chemical species that inhibit viral DNA synthesis. The inhibition involves incorporation of ddNMP into DNA and subsequent chain termination. A conceivable...
6.
Wang G, Boyle N, Chen F, Rajappan V, Fagan P, Brooks J, et al.
J Med Chem
. 2004 Dec;
47(27):6902-13.
PMID: 15615539
In search of active nucleoside 5'-triphosphate mimics, we have synthesized a series of AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well as...
7.
Wang G, Sakthivel K, Rajappan V, Bruice T, Tucker K, Fagan P, et al.
Nucleosides Nucleotides Nucleic Acids
. 2004 Mar;
23(1-2):317-37.
PMID: 15043157
IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5'-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases...
8.
Zaslow M, Moore K, Brooks J, Morris P, Tout K, Redd Z, et al.
Future Child
. 2002 May;
12(1):78-95.
PMID: 11980040
Even prior to passage of federal welfare reform, many demonstration programs anticipated key features of the 1996 law, such as "work-first" strategies, time limits on welfare receipt, and financial incentives...