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» Authors » Marija Prhavc

Marija Prhavc

Explore the profile of Marija Prhavc including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 385
Followers 0
Related Specialties
Chemistry
Biochemistry
General Medicine
Top 10 Co-Authors
Guangyi Wang
P Dan Cook
Natalia Dyatkina
Zhinan Jin
Jerome Deval
Thazha P Prakash
Amy Fung
Vivek K Rajwanshi
Yuen Tam
David B Smith
Published In
J Med Chem
Nucleosides Nucleotides Nucleic Acids
Org Lett
J Am Chem Soc
PLoS Pathog
Affiliations
Soon will be listed here.
Recent Articles
1.
Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides
Holan M, Tucker K, Dyatkina N, Liu H, Kinkade A, Wang G, et al.
Molecules . 2022 Apr; 27(8). PMID: 35458620
Nucleoside analogues have excellent records as anti-HBV drugs. Chronic infections require long-term administration ultimately leading to drug resistance. Therefore, the search for nucleosides with novel scaffolds is of high importance....
2.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C
Wang G, Dyatkina N, Prhavc M, Williams C, Serebryany V, Hu Y, et al.
J Med Chem . 2020 Aug; 63(18):10380-10395. PMID: 32816483
Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%; however, the...
3.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection
Wang G, Dyatkina N, Prhavc M, Williams C, Serebryany V, Hu Y, et al.
J Med Chem . 2019 Apr; 62(9):4555-4570. PMID: 30951311
We report the synthesis and biological evaluation of a series of 4'-fluoro-2'- C-substituted uridines. Triphosphates of the uridine analogues exhibited a potent inhibition of hepatitis C virus (HCV) NS5B polymerase...
4.
Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase
Deval J, Fung A, Stevens S, Jordan P, Gromova T, Taylor J, et al.
PLoS One . 2016 May; 11(5):e0154097. PMID: 27163448
ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by...
5.
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues
Wang G, Wan J, Hu Y, Wu X, Prhavc M, Dyatkina N, et al.
J Med Chem . 2016 Apr; 59(10):4611-24. PMID: 27120583
Influenza viruses are responsible for seasonal epidemics and occasional pandemics which cause significant morbidity and mortality. Despite available vaccines, only partial protection is achieved. Currently, there are two classes of...
6.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
Deval J, Hong J, Wang G, Taylor J, Smith L, Fung A, et al.
PLoS Pathog . 2015 Jun; 11(6):e1004995. PMID: 26098424
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers,...
7.
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection
Wang G, Deval J, Hong J, Dyatkina N, Prhavc M, Taylor J, et al.
J Med Chem . 2015 Feb; 58(4):1862-78. PMID: 25667954
Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality. To date, ribavirin is the only approved small molecule drug, which has...
8.
Synthesis and biological activity of 7-deaza-7-ethynyl-2'-deoxy-2'-fluoro-2'-C-methyladenosine and its 2'-C-methyl-ribo analogue
Prhavc M, Dyatkina N, Keicher J, Liehr S, Koo-McCoy S, Latour D, et al.
Nucleic Acids Symp Ser (Oxf) . 2008 Sep; (52):643-4. PMID: 18776544
In our search for improved therapeutic agents against HCV we synthesized 7-deaza-7-ethynyl-2'-C-methyladenosine (1) and its 2'-deoxy-2'-fluoro analogue 2. The corresponding nucleoside triphosphates were efficient chain terminators of the HCV NS5b...
9.
2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase
Boyle N, Fagan P, Brooks J, Prhavc M, Lambert J, Cook P
Nucleosides Nucleotides Nucleic Acids . 2006 Jan; 24(10-12):1651-64. PMID: 16438041
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs which require three intracellular phosphorylation steps to yield their corresponding, biologically active, nucleoside triphosphate. In order to circumvent this often inefficient phosphorylation cascade,...
10.
Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors
Rajwanshi V, Prhavc M, Fagan P, Brooks J, Hurd T, Cook P, et al.
Nucleosides Nucleotides Nucleic Acids . 2005 May; 24(3):179-89. PMID: 15892257
3'-Azido-3',5-dideoxythymidine 5'-phosphonate and 3',5'-dideoxy-5'-difluoromethylenethymidine 5'-phosphonate were prepared by multistep syntheses. The nucleoside 5'-phosphonates were converted to their triphosphates and triphosphate mimics (P3Ms) containing beta,gamma-difluoromethylene, beta,gamma-dichloromethylene, or beta,gamma-imodo by condensation with...