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Jennifer D Young

Explore the profile of Jennifer D Young including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 172
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Recent Articles
1.
Pham T, Hungnes I, Rivas C, Cleaver J, Firth G, Blower P, et al.
J Nucl Med . 2024 Jun; 65(7):1087-1094. PMID: 38844360
Benchtop Mo/Tc and W/Re generators enable economical production of molecular theranostic Tc and Re radiopharmaceuticals, provided that simple, kit-based chemistry exists to radiolabel targeting vectors with these radionuclides. We have...
2.
Ree S, Greenwood H, Young J, Roberts R, Livens F, Heath S, et al.
Nucl Med Commun . 2024 Mar; 45(6):465-473. PMID: 38465420
Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease sites. The high energy and high linear energy transfer associated...
3.
Hungnes I, Pham T, Rivas C, Jarvis J, Nuttall R, Cooper S, et al.
Inorg Chem . 2023 Mar; 62(50):20608-20620. PMID: 36972174
We have developed a diphosphine (DP) platform for radiolabeling peptides with Tc and Cu for molecular SPECT and PET imaging, respectively. Two diphosphines, 2,3-bis(diphenylphosphino)maleic anhydride (DP) and 2,3-bis(di--tolylphosphino)maleic anhydride (DP),...
4.
Cusnir R, Cakebread A, Cooper M, Young J, Blower P, Ma M
RSC Adv . 2022 May; 9(64):37214-37221. PMID: 35542301
GMP-grade Ge/Ga generators provide access to positron-emitting Ga, enabling preparation of Positron Emission Tomography (PET) tracers and PET imaging at sites that do not have access to cyclotron-produced radionuclides. Radiotracers...
5.
Young J, Jauregui-Osoro M, Wong W, Cooper M, Cook G, Barrington S, et al.
Nucl Med Commun . 2021 Jul; 42(12):1301-1312. PMID: 34284442
Background And Objectives: Nuclear medicine contributes greatly to the clinical management of patients and experimental medicine. This report aims to (1) outline the current landscape of nuclear medicine research in...
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Young J, Ma M, Eykyn T, Atkinson R, Abbate V, Cilibrizzi A, et al.
Bioorg Med Chem Lett . 2021 Apr; 42:128044. PMID: 33865971
Glutamate carboxypeptidase II (GCP(II)), also known as the prostate-specific membrane antigen (PSMA), is a transmembrane zinc(II) metalloenzyme overexpressed in prostate cancer. Inhibitors of this receptor are used to target molecular...
8.
Imberti C, Chen Y, Foley C, Ma M, Paterson B, Wang Y, et al.
Dalton Trans . 2019 Mar; 48(13):4299-4313. PMID: 30860215
The prototype tris(1,6-dimethyl-3-hydroxypyridin-4-one) chelator for gallium-68, THPMe, has shown great promise for rapid and efficient kit-based 68Ga labelling of PET radiopharmaceuticals. Peptide derivatives of THPMe have been used to image...
9.
Southworth R, Torres Martin de Rosales R, Meszaros L, Ma M, Mullen G, Fruhwirth G, et al.
Adv Inorg Chem . 2018 Nov; 68:1-41. PMID: 30381783
The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply...
10.
Tsionou M, Knapp C, Foley C, Munteanu C, Cakebread A, Imberti C, et al.
RSC Adv . 2018 Jan; 7(78):49586-49599. PMID: 29308192
Gallium-68 (Ga) is a positron-emitting isotope used for clinical PET imaging of peptide receptor expression. Ga radiopharmaceuticals used in molecular PET imaging consist of disease-targeting biomolecules tethered to chelators that...