Jeffrey Weidlick
Overview
Explore the profile of Jeffrey Weidlick including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
189
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0
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Recent Articles
1.
Vitale L, He L, Thomas L, Wasiuk A, ONeill T, Widger J, et al.
Cancer Immunol Immunother
. 2020 May;
69(10):2125-2137.
PMID: 32451681
CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1 checkpoint axis on T cells. Combining a CD27 agonist antibody with PD-1/PD-L1 blockade has shown synergistic antitumor...
2.
Vitale L, Thomas L, He L, ONeill T, Widger J, Crocker A, et al.
Cancer Immunol Immunother
. 2018 Nov;
68(2):233-245.
PMID: 30382327
Limitations of immunotherapy include poorly functioning events early in the immune response cycle, such as efficient antigen presentation and T cell priming. CD40 signaling in dendritic cells leads to upregulation...
3.
Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine
He L, Weidlick J, Sisson C, Marsh H, Keler T
Cell Mol Immunol
. 2014 Oct;
12(6):719-28.
PMID: 25345808
Previous studies have documented that selective delivery of protein antigens to cells expressing mannose receptor (MR) can lead to enhanced immune responses. We postulated that agents that influenced the MR...
4.
He L, Prostak N, Thomas L, Vitale L, Weidlick J, Crocker A, et al.
J Immunol
. 2013 Sep;
191(8):4174-83.
PMID: 24026078
The CD70/CD27 pathway plays a significant role in the control of immunity and tolerance, and previous studies demonstrated that targeting murine CD27 (mCD27) with agonist mAbs can mediate antitumor efficacy....
5.
Vitale L, He L, Thomas L, Widger J, Weidlick J, Crocker A, et al.
Clin Cancer Res
. 2012 May;
18(14):3812-21.
PMID: 22589397
Purpose: The TNF receptor superfamily member CD27 is best known for its important role in T-cell immunity but is also recognized as a cell-surface marker on a number of B-...
6.
Hayward M, Jones B, Saparov A, Hain H, Trillat A, Bunzel M, et al.
BMC Physiol
. 2007 Dec;
7:13.
PMID: 18070349
Background: Tumor necrosis factor alpha (TNFalpha) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice...