Jeffrey Malik
Overview
Explore the profile of Jeffrey Malik including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
566
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0
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Recent Articles
1.
Schroeder G, Akinyemi O, Malik J, Focht C, Pritchett E, Baker C, et al.
Nucleic Acids Res
. 2023 Feb;
51(5):2464-2484.
PMID: 36762498
Riboswitches regulate downstream gene expression by binding cellular metabolites. Regulation of translation initiation by riboswitches is posited to occur by metabolite-mediated sequestration of the Shine-Dalgarno sequence (SDS), causing bypass by...
2.
Nemkov T, Kingsley P, Dzieciatkowska M, Malik J, McGrath K, Hansen K, et al.
Blood Adv
. 2022 Feb;
6(10):3072-3089.
PMID: 35139174
Primitive erythropoiesis is a critical component of the fetal cardiovascular network and is essential for the growth and survival of the mammalian embryo. The need to rapidly establish a functional...
3.
Myers J, Couch T, Murphy Z, Malik J, Getman M, Steiner L
Epigenetics Chromatin
. 2020 Mar;
13(1):16.
PMID: 32178723
Background: SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression,...
4.
Herbert Z, Thimmapuram J, Xie S, Kershner J, Kolling F, Ringelberg C, et al.
J Biomol Tech
. 2020 Jan;
31(2):47-56.
PMID: 31966025
Small RNAs (smRNAs) are important regulators of many biologic processes and are now most frequently characterized using Illumina sequencing. However, although standard RNA sequencing library preparation has become routine in...
5.
Malik J, Lillis J, Couch T, Getman M, Steiner L
Cell Rep
. 2017 Nov;
21(9):2376-2383.
PMID: 29186677
Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process. Setd8 is...
6.
Sollinger C, Lillis J, Malik J, Getman M, Proschel C, Steiner L
Sci Rep
. 2017 Nov;
7(1):14381.
PMID: 29084993
Erythropoietin (EPO) and its receptor are highly expressed in the developing nervous system, and exogenous EPO therapy is potentially neuroprotective, however the epigenetic and transcriptional changes downstream of EPO signaling...
7.
Malik J, Getman M, Steiner L
Mol Cell Biol
. 2015 Apr;
35(12):2059-72.
PMID: 25848090
Setd8 is the sole histone methyltransferase in mammals capable of monomethylating histone H4 lysine 20 (H4K20me1). Setd8 is expressed at significantly higher levels in erythroid cells than any other cell...
8.
Malik J, Kim A, Tyre K, Cherukuri A, Palis J
Haematologica
. 2013 Jul;
98(11):1778-87.
PMID: 23894012
Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely required for survival of late-stage...
9.
Greenfest-Allen E, Malik J, Palis J, Stoeckert Jr C
BMC Syst Biol
. 2013 May;
7:38.
PMID: 23675896
Background: Hematopoietic ontogeny is characterized by overlapping waves of primitive, fetal definitive, and adult definitive erythroid lineages. Our aim is to identify differences in the transcriptional control of these distinct...
10.
Kingsley P, Greenfest-Allen E, Frame J, Bushnell T, Malik J, McGrath K, et al.
Blood
. 2012 Dec;
121(6):e5-e13.
PMID: 23243273
Erythroid ontogeny is characterized by overlapping waves of primitive and definitive erythroid lineages that share many morphologic features during terminal maturation but have marked differences in cell size and globin...