Jeffrey M Beekman
Overview
Explore the profile of Jeffrey M Beekman including associated specialties, affiliations and a list of published articles.
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Articles
93
Citations
4224
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Recent Articles
1.
Pleguezuelos-Manzano C, Beenker W, van Son G, Begthel H, Amatngalim G, Beekman J, et al.
Sci Rep
. 2025 Jan;
15(1):2222.
PMID: 39824906
Pseudomonas aeruginosa is a Gram-negative bacterium that is notorious for airway infections in cystic fibrosis (CF) subjects. Bacterial quorum sensing (QS) coordinates virulence factor expression and biofilm formation at population...
2.
Kroes S, Bierlaagh M, Lefferts J, Boni A, Muilwijk D, Viscomi C, et al.
J Cyst Fibros
. 2024 Nov;
24(1):175-182.
PMID: 39523185
Cystic fibrosis is a life-shortening genetic disease caused by pathological variants of the cystic fibrosis transmembrane conductance regulator gene. The CFTR modulator therapy elexacaftor, tezacaftor and ivacaftor (ETI) rescues CFTR...
3.
Stege P, Beekman J, Hendrickx A, van Eijk L, Rogers M, Suen S, et al.
FEMS Microbes
. 2024 May;
5:xtae014.
PMID: 38813098
is an opportunistic pathogen able to colonize the intestines of hospitalized patients. This initial colonization is an important step in the downstream pathogenesis, which includes outgrowth of the intestinal microbiota...
4.
Bierlaagh M, van Mourik P, Vonk A, Pott J, Muilwijk D, Berkers G, et al.
J Cyst Fibros
. 2024 May;
23(4):703-706.
PMID: 38763840
Background: Patient-derived intestinal organoids (PDIOs) show great potential as in vitro drug testing platform for personalised medicine in Cystic Fibrosis and oncology. PDIOs can be generated by culturing adult stem...
5.
Bierlaagh M, Ramalho A, Silva I, Vonk A, van den Bor R, van Mourik P, et al.
J Cyst Fibros
. 2024 May;
23(4):693-702.
PMID: 38749892
Background: The forskolin-induced swelling (FIS) assay measures CFTR function on patient-derived intestinal organoids (PDIOs) and may guide treatment selection for individuals with Cystic Fibrosis (CF). The aim of this study...
6.
Lefferts J, Kroes S, Smith M, Niemoller P, Nieuwenhuijze N, Sonneveld van Kooten H, et al.
Commun Biol
. 2024 Mar;
7(1):319.
PMID: 38480810
Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties in PDOs can...
7.
Delpiano L, Rodenburg L, Burke M, Nelson G, Amatngalim G, Beekman J, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2307551120.
PMID: 37967223
In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises innate defence mechanisms, predisposing to pulmonary failure....
8.
Rodenburg L, Metzemaekers M, van der Windt I, Smits S, den Hertog-Oosterhoff L, Kruisselbrink E, et al.
Sci Rep
. 2023 Oct;
13(1):18573.
PMID: 37903789
The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal and bronchial...
9.
Lefferts J, Bierlaagh M, Kroes S, Nieuwenhuijze N, Sonneveld van Kooten H, Niemoller P, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37833986
Cystic fibrosis (CF) is caused by mutations in the () gene. The combination of the CFTR modulators elexacaftor, tezacaftor, and ivacaftor (ETI) enables the effective rescue of CFTR function in...
10.
Dreyer H, van Tuyll van Serooskerken E, Rodenburg L, Bittermann A, Arets H, Reuling E, et al.
Children (Basel)
. 2023 Jun;
10(6).
PMID: 37371252
Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory tract disorders are in part caused...