Jeffrey K Griffith
Overview
Explore the profile of Jeffrey K Griffith including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
596
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Recent Articles
1.
Vaughan R, Garcia-Smith R, Dorsey J, Griffith J, Bisoffi M, Trujillo K
Int J Cancer
. 2013 May;
133(10):2504-10.
PMID: 23661584
The reprogramming of cellular metabolism in cancer cells is a well-documented effect. It has previously been shown that common oncogene expression can induce aerobic glycolysis in cancer cells. However, the...
2.
Heaphy C, Bisoffi M, Griffith J
Expert Opin Med Diagn
. 2013 Mar;
1(2):159-68.
PMID: 23489303
Allelic imbalance (AI), a deviation from the normal 1:1 ratio of maternal and paternal alleles, occurs in virtually all solid and blood-borne malignancies. The frequency and spectrum of AI in...
3.
Butler K, Hines W, Heaphy C, Griffith J
Cancer Med
. 2013 Jan;
1(2):165-75.
PMID: 23342266
Telomere dysregulation occurs in both the in situ and invasive stages of many carcinomas, including breast. Knockout experiments have identified several telomere-associated proteins required for proper telomere function and maintenance,...
4.
Garcia-Rizo C, Fernandez-Egea E, Miller B, Oliveira C, Justicia A, Griffith J, et al.
Brain Behav Immun
. 2012 Dec;
28:49-53.
PMID: 23207109
Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined...
5.
The clinical significance of inflammatory cytokines in primary cell culture in endometrial carcinoma
Smith H, Stephens N, Qualls C, Fligelman T, Wang T, Lin C, et al.
Mol Oncol
. 2012 Sep;
7(1):41-54.
PMID: 22944067
Endometrial cancer is the most common malignancy of the female genital tract, and the incidence and mortality rates from this disease are increasing. Although endometrial carcinoma has been regarded as...
6.
Trujillo K, Jones A, Griffith J, Bisoffi M
Prostate Cancer
. 2012 Jun;
2012:302894.
PMID: 22666601
Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field...
7.
Jones A, Trujillo K, Phillips G, Fleet T, Murton J, Severns V, et al.
Prostate
. 2011 Dec;
72(11):1159-70.
PMID: 22127986
Background: Field cancerization denotes the occurrence of molecular alterations in histologically normal tissues adjacent to tumors. In prostate cancer, identification of field cancerization has several potential clinical applications. However, prostate...
8.
Trujillo K, Hines W, Vargas K, Jones A, Joste N, Bisoffi M, et al.
Mol Cancer Res
. 2011 Jul;
9(9):1209-21.
PMID: 21775421
Telomerase stabilizes chromosomes by maintaining telomere length, immortalizes mammalian cells, and is expressed in more than 90% of human tumors. However, the expression of human telomerase reverse transcriptase (hTERT) is...
9.
Trujillo K, Heaphy C, Mai M, Vargas K, Jones A, Vo P, et al.
Int J Cancer
. 2010 Nov;
129(6):1310-21.
PMID: 21105047
Previous studies have shown that a field of genetically altered but histologically normal tissue extends 1 cm or more from the margins of human breast tumors. The extent, composition and...
10.
Heaphy C, Fleet T, Treat E, Lee S, Smith A, Davis M, et al.
Prostate
. 2010 Aug;
70(13):1471-9.
PMID: 20687220
Background: Telomere attrition occurs early in the development of prostatic adenocarcinoma. However, little is known about either telomere status in benign prostatic hyperplasia (BPH), or the spatial and organ-wide distribution...