Jeffrey G Mellott
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Explore the profile of Jeffrey G Mellott including associated specialties, affiliations and a list of published articles.
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29
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347
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Recent Articles
1.
Noftz W, Echols E, Beebe N, Mellott J, Schofield B
J Chem Neuroanat
. 2024 Jun;
139:102443.
PMID: 38914378
The inferior colliculus (IC), a midbrain hub for integration of auditory information, receives dense cholinergic input that could modulate nearly all aspects of hearing. A key step in understanding cholinergic...
2.
Mellott J, Duncan S, Busby J, Almassri L, Wawrzyniak A, Iafrate M, et al.
Front Cell Neurosci
. 2024 May;
18():1396387.
PMID: 38774486
Presbycusis is one of the most prevalent disabilities in aged populations of industrialized countries. As we age less excitation reaches the central auditory system from the periphery. To compensate, the...
3.
Koehler C, Almassri L, Tokar N, Mafi A, OHara M, Young J, et al.
Transl Med Aging
. 2023 Dec;
7:20-32.
PMID: 38111912
Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However,...
4.
Almassri L, Ohl A, Iafrate M, Wade A, Tokar N, Mafi A, et al.
Front Aging Neurosci
. 2023 Dec;
15:1271008.
PMID: 38053844
Introduction: Disruptions to the balance of excitation and inhibition in the inferior colliculus (IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age-related alteration to GABAergic...
5.
Haragopal H, Mellott J, Dhar M, Kanel A, Mafi A, Tokar N, et al.
J Comp Neurol
. 2023 Jul;
531(14):1381-1388.
PMID: 37436768
The principal neurons (PNs) of the lateral superior olive nucleus (LSO) are an important component of mammalian brainstem circuits that compare activity between the two ears and extract intensity and...
6.
Weil B, Allen S, Barbaccia T, Wong K, Beaver A, Slabinski E, et al.
Resuscitation
. 2023 Feb;
186:109735.
PMID: 36806653
Background: Given emerging evidence of rapid non-genomic cytoprotective effects of triiodothyronine (T3), we evaluated the resuscitative efficacy of two nanoparticle formulations of T3 (T3np) designed to prolong cell membrane receptor-mediated...
7.
Mafi A, Tokar N, Russ M, Barat O, Mellott J
Neurobiol Aging
. 2022 Sep;
120:43-59.
PMID: 36116395
Temporal precision, a key component of sound and speech processing in the inferior colliculus (IC), depends on a balance of inhibition and excitation, and this balance degrades during aging. The...
8.
Noftz W, Beebe N, Mellott J, Schofield B
Hear Res
. 2021 Sep;
411:108352.
PMID: 34564033
Cholinergic axons from the pedunculopontine tegmental nucleus (PPT) innervate the inferior colliculus where they are positioned to modulate both excitatory and inhibitory circuits across the central nucleus and adjacent cortical...
9.
Mellott J, Dhar M, Mafi A, Tokar N, Winters B
J Comp Neurol
. 2021 Aug;
530(2):506-517.
PMID: 34338321
Sound localization critically relies on brainstem neurons that compare information from the two ears. The conventional role of the lateral superior olive (LSO) is extraction of intensity differences; however, it...
10.
Mafi A, Russ M, Hofer L, Pham V, Young J, Mellott J
Neurobiol Aging
. 2021 May;
105:1-15.
PMID: 34004491
The age-related loss of GABA in the inferior colliculus (IC) likely plays a role in the development of age-related hearing loss. Perineuronal nets (PNs), specialized aggregates of extracellular matrix, increase...