Jeffrey D Hildebrand
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Explore the profile of Jeffrey D Hildebrand including associated specialties, affiliations and a list of published articles.
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20
Citations
975
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Recent Articles
1.
Hildebrand J, Leventry A, Aideyman O, Majewski J, Haddad J, Bisi D, et al.
Biol Open
. 2021 Jan;
10(2).
PMID: 33504488
Regulation of cell architecture is critical in the formation of tissues during animal development. The mechanisms that control cell shape must be both dynamic and stable in order to establish...
2.
Zalewski J, Heber S, Mo J, OConor K, Hildebrand J, VanDemark A
J Vis Exp
. 2017 Jan;
(119).
PMID: 28117766
Obtaining crystals for structure determination can be a difficult and time consuming proposition for any protein. Coiled-coil proteins and domains are found throughout nature, however, because of their physical properties...
3.
Zalewski J, Mo J, Heber S, Heroux A, Gardner R, Hildebrand J, et al.
J Biol Chem
. 2016 Oct;
291(49):25364-25374.
PMID: 27758857
Shroom-mediated remodeling of the actomyosin cytoskeleton is a critical driver of cellular shape and tissue morphology that underlies the development of many tissues including the neural tube, eye, intestines, and...
4.
McGreevy E, Vijayraghavan D, Davidson L, Hildebrand J
Biol Open
. 2015 Jan;
4(2):186-96.
PMID: 25596276
Neural tube closure is a critical developmental event that relies on actomyosin contractility to facilitate specific processes such as apical constriction, tissue bending, and directional cell rearrangements. These complicated processes...
5.
Das D, Zalewski J, Mohan S, Plageman T, VanDemark A, Hildebrand J
Biol Open
. 2014 Aug;
3(9):850-60.
PMID: 25171888
Shroom3 is an actin-associated regulator of cell morphology that is required for neural tube closure, formation of the lens placode, and gut morphogenesis in mice and has been linked to...
6.
Lang R, Herman K, Reynolds A, Hildebrand J, Plageman Jr T
Development
. 2014 Jul;
141(16):3177-87.
PMID: 25038041
Apical constriction (AC) is a widely utilized mechanism of cell shape change whereby epithelial cells transform from a cylindrical to conical shape, which can facilitate morphogenetic movements during embryonic development....
7.
Mohan S, Das D, Bauer R, Heroux A, Zalewski J, Heber S, et al.
PLoS One
. 2013 Dec;
8(12):e81075.
PMID: 24349032
Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date. One of the primary effectors...
8.
Mohan S, Rizaldy R, Das D, Bauer R, Heroux A, Trakselis M, et al.
Mol Biol Cell
. 2012 Apr;
23(11):2131-42.
PMID: 22493320
Shroom (Shrm) proteins are essential regulators of cell shape and tissue morpho-logy during animal development that function by interacting directly with the coiled-coil region of Rho kinase (Rock). The Shrm-Rock...
9.
Plageman Jr T, Chauhan B, Yang C, Jaudon F, Shang X, Zheng Y, et al.
Development
. 2011 Oct;
138(23):5177-88.
PMID: 22031541
Epithelial invagination is a common feature of embryogenesis. An example of invagination morphogenesis occurs during development of the early eye when the lens placode forms the lens pit. This morphogenesis...
10.
Grosse A, Pressprich M, Curley L, Hamilton K, Margolis B, Hildebrand J, et al.
Development
. 2011 Sep;
138(20):4423-32.
PMID: 21880782
The cellular mechanisms that drive growth and remodeling of the early intestinal epithelium are poorly understood. Current dogma suggests that the murine fetal intestinal epithelium is stratified, that villi are...