Jeffrey A Speir
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Explore the profile of Jeffrey A Speir including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
709
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Recent Articles
1.
Rush B, Djagbare M, Speir J, Sanyal G
J Virol
. 2020 Sep;
94(22).
PMID: 32878888
A genetically modified, recombinant form of Newcastle disease virus (rNDV) undergoes ionic strength-dependent changes in morphology, as observed by cryo-electron microscopy (cEM). In hypotonic solutions with ionic strengths ranging from ...
2.
Yap M, Klose T, Arisaka F, Speir J, Veesler D, Fokine A, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(10):2654-9.
PMID: 26929357
Bacteriophage T4 consists of a head for protecting its genome and a sheathed tail for inserting its genome into a host. The tail terminates with a multiprotein baseplate that changes...
3.
Zhao H, Speir J, Matsui T, Lin Z, Liang L, Lynn A, et al.
PLoS One
. 2016 Feb;
11(2):e0149337.
PMID: 26882199
The multi-layered cell envelope structure of Gram-negative bacteria represents significant physical and chemical barriers for short-tailed phages to inject phage DNA into the host cytoplasm. Here we show that a...
4.
Short J, Speir J, Gopal R, Pankratz L, Lanman J, Schneemann A
J Virol
. 2016 Jan;
90(7):3676-83.
PMID: 26792749
Unlabelled: Viruses that generate double-stranded RNA (dsRNA) during replication must overcome host defense systems designed to detect this infection intermediate. All positive-sense RNA viruses studied to date modify host membranes...
5.
Kuruganti S, Miersch S, Deshpande A, Speir J, Harris B, Schriewer J, et al.
J Biol Chem
. 2015 Nov;
291(1):447-61.
PMID: 26546677
Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we developed antibody-based activators of cytokine signaling (AcCS), which...
6.
Mulligan S, Speir J, Razinkov I, Cheng A, Crum J, Jain T, et al.
Microsc Microanal
. 2015 Jul;
21(4):1017-1025.
PMID: 26223550
We describe a system for rapidly screening hundreds of nanoparticle samples using transmission electron microscopy (TEM). The system uses a liquid handling robot to place up to 96 individual samples...
7.
Ye Q, Rosenberg S, Moeller A, Speir J, Su T, Corbett K
Elife
. 2015 Apr;
4.
PMID: 25918846
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present...
8.
Moeller A, Lee S, Tao H, Speir J, Chang G, Urbatsch I, et al.
Structure
. 2015 Feb;
23(3):450-460.
PMID: 25661651
ATP-binding cassette (ABC) exporters are ubiquitously found in all kingdoms of life and their members play significant roles in mediating drug pharmacokinetics and multidrug resistance in the clinic. Significant questions...
9.
Leung J, Schurig-Briccio L, Yamaguchi M, Moeller A, Speir J, Gennis R, et al.
Science
. 2015 Jan;
347(6218):178-81.
PMID: 25574024
NADPH/NADP(+) (the reduced form of NADP(+)/nicotinamide adenine dinucleotide phosphate) homeostasis is critical for countering oxidative stress in cells. Nicotinamide nucleotide transhydrogenase (TH), a membrane enzyme present in both bacteria and...
10.
Bhabha G, Cheng H, Zhang N, Moeller A, Liao M, Speir J, et al.
Cell
. 2014 Nov;
159(4):857-68.
PMID: 25417161
Dyneins power microtubule motility using ring-shaped, AAA-containing motor domains. Here, we report X-ray and electron microscopy (EM) structures of yeast dynein bound to different ATP analogs, which collectively provide insight...