Jeffrey A Kiefer
Overview
Explore the profile of Jeffrey A Kiefer including associated specialties, affiliations and a list of published articles.
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16
Citations
577
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Recent Articles
1.
LoRusso P, Sekulic A, Sosman J, Liang W, Carpten J, Craig D, et al.
PLoS One
. 2021 Apr;
16(4):e0248097.
PMID: 33826614
Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted agents have been ineffective for BRAFV600wild-type (wt) metastatic melanomas. The...
2.
Weiss G, Byron S, Aldrich J, Sangal A, Barilla H, Kiefer J, et al.
PLoS One
. 2017 Jun;
12(6):e0179170.
PMID: 28586388
Background: Small cell lung cancer (SCLC) that has progressed after first-line therapy is an aggressive disease with few effective therapeutic strategies. In this prospective study, we employed next-generation sequencing (NGS)...
3.
Lewis E, David V, Doyle A, Rajabi K, Kiefer J, Pirrotte P, et al.
Eukaryot Cell
. 2015 Aug;
14(10):1043-53.
PMID: 26275879
Coccidioides immitis and Coccidioides posadasii are soil-dwelling fungi and the causative agents of coccidioidomycosis, a mycosis endemic to certain semiarid regions in the Americas. The most common route of infection...
4.
Van Keuren-Jensen K, Malenica I, Courtright A, Ghaffari L, Starr A, Metpally R, et al.
Liver Int
. 2015 Jul;
36(3):334-43.
PMID: 26189820
Background & Aims: Accumulating evidence indicates that microRNAs play a role in a number of disease processes including the pathogenesis of liver fibrosis in hepatitis C infection. Our goal is...
5.
LoRusso P, Boerner S, Pilat M, Forman K, Zuccaro C, Kiefer J, et al.
Mol Cancer Ther
. 2015 Jun;
14(8):1962-71.
PMID: 26063764
Targeted therapies and immunotherapies have led to significant improvements in the treatment of advanced cancers, including metastatic melanoma. However, new strategies are desperately needed to overcome therapeutic resistance to these...
6.
Zhang L, Zhang Y, Mehta A, Boufraqech M, Davis S, Wang J, et al.
Oncotarget
. 2015 May;
6(11):9073-85.
PMID: 25940539
Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently has no effective therapy. We performed quantitative high-throughput screening (qHTS) in three ATC cell lines using...
7.
Prados M, Byron S, Tran N, Phillips J, Molinaro A, Ligon K, et al.
Neuro Oncol
. 2015 May;
17(8):1051-63.
PMID: 25934816
Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have identified various therapeutic opportunities across cancer subsets. Despite pivotal...
8.
Sekulic A, Liang W, Tembe W, Izatt T, Kruglyak S, Kiefer J, et al.
Mol Genet Genomic Med
. 2015 Mar;
3(2):130-6.
PMID: 25802883
Matching molecularly targeted therapies with cancer subtype-specific gene mutations is revolutionizing oncology care. However, for rare cancers this approach is problematic due to the often poor understanding of the disease's...
9.
Craig D, OShaughnessy J, Kiefer J, Aldrich J, Sinari S, Moses T, et al.
Mol Cancer Ther
. 2012 Nov;
12(1):104-16.
PMID: 23171949
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after first-line treatment, and metastatic TNBC (mTNBC)...
10.
Liang W, Craig D, Carpten J, Borad M, Demeure M, Weiss G, et al.
PLoS One
. 2012 Oct;
7(10):e43192.
PMID: 23071490
Pancreatic adenocarcinoma (PAC) is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently...