Jeffery L Miller
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Explore the profile of Jeffery L Miller including associated specialties, affiliations and a list of published articles.
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58
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2276
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Recent Articles
1.
Chambers C, Gross J, Pratt K, Guo X, Byrnes C, Lee Y, et al.
Mol Ther Methods Clin Dev
. 2020 Mar;
17:429-440.
PMID: 32154328
Sickle cell disease (SCD) and β-thalassemia are caused by structural abnormality or inadequate production of adult hemoglobin (HbA, αβ), respectively. Individuals with either disorder are asymptomatic before birth because fetal...
2.
Montemayor-Garcia C, Karagianni P, Stiles D, Reese E, Smellie D, Loy D, et al.
Transfusion
. 2018 Oct;
58(11):2693-2704.
PMID: 30312480
Background: The 1000 Genomes Project provides a database of genomic variants from whole genome sequencing of 2504 individuals across five continental superpopulations. This database can enrich our background knowledge of...
3.
de Vasconcellos J, Byrnes C, Lee Y, Allwardt J, Kaushal M, Rabel A, et al.
J Transl Med
. 2017 Aug;
15(1):169.
PMID: 28768505
Background: In humans, the heterochronic cascade composed of the RNA-binding protein LIN28 and its major target, the let-7 family of microRNAs (miRNAs), is highly regulated during human erythroid ontogeny. Additionally,...
4.
de Vasconcellos J, Tumburu L, Byrnes C, Lee Y, Xu P, Li M, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(28):E5664-E5672.
PMID: 28652347
Here we investigated in primary human erythroid tissues a downstream element of the heterochronic miRNA pathway, the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), for its potential to affect...
5.
Li Q, Henry E, Hofrichter J, Smith J, Cellmer T, Dunkelberger E, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(5):E689-E696.
PMID: 28096387
Although it has been known for more than 60 years that the cause of sickle cell disease is polymerization of a hemoglobin mutant, hydroxyurea is the only drug approved for...
6.
de Vasconcellos J, Lee Y, Byrnes C, Tumburu L, Rabel A, Miller J
PLoS One
. 2016 Nov;
11(11):e0166928.
PMID: 27861570
Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the fetal-to-adult developmental...
7.
Kaushal M, Byrnes C, Khademian Z, Duncan N, Luban N, Miller J, et al.
PLoS One
. 2016 Apr;
11(4):e0153244.
PMID: 27116614
Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA...
8.
Lee Y, de Vasconcellos J, Byrnes C, Kaushal M, Rabel A, Tumburu L, et al.
PLoS One
. 2015 Dec;
10(12):e0144977.
PMID: 26675483
Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression for its effect in regulating gamma-globin gene expression and...
9.
Stroncek D, Tran M, Frodigh S, David-Ocampo V, Ren J, Larochelle A, et al.
Transfusion
. 2015 Oct;
56(2):511-7.
PMID: 26505619
Background: Cell selection is an important part of manufacturing cellular therapies. A new highly automated instrument, the CliniMACS Prodigy (Miltenyi Biotec), was evaluated for the selection of CD34+ cells from...
10.
Meier E, Byrnes C, Weissman M, Lee Y, Miller J
PLoS One
. 2015 Sep;
10(9):e0136672.
PMID: 26366562
Hemoglobin switching is largely complete in humans by six months of age. Among infants with sickle cell anemia (HbSS, SCA), reticulocytosis begins early in life as fetal hemoglobin (HbF) is...