Jeff Bolstad
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Explore the profile of Jeff Bolstad including associated specialties, affiliations and a list of published articles.
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10
Citations
397
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Recent Articles
1.
Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, et al.
Nat Med
. 2014 Jan;
20(2):184-92.
PMID: 24441828
Spontaneous Ca(2+) release from intracellular stores is important for various physiological and pathological processes. In cardiac muscle cells, spontaneous store overload-induced Ca(2+) release (SOICR) can result in Ca(2+) waves, a...
2.
Hirota S, Iablokov V, Tulk S, Schenck L, Becker H, Nguyen J, et al.
Infect Immun
. 2012 Oct;
80(12):4474-84.
PMID: 23045481
Clostridium difficile, a major cause of hospital-acquired diarrhea, triggers disease through the release of two toxins, toxin A (TcdA) and toxin B (TcdB). These toxins disrupt the cytoskeleton of the...
3.
Jones P, Jiang D, Bolstad J, Hunt D, Zhang L, Demaurex N, et al.
Biochem J
. 2007 Dec;
412(1):171-8.
PMID: 18092949
A number of RyR2 (cardiac ryanodine receptor) mutations linked to ventricular arrhythmia and sudden death are located within the last C-terminal approximately 500 amino acid residues, which is believed to...
4.
Jones P, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, et al.
Biochem J
. 2007 Oct;
410(2):261-70.
PMID: 17967164
PKA (protein kinase A)-dependent phosphorylation of the cardiac Ca2+-release channel/RyR2 (type 2 ryanodine receptor)is believed to directly dissociate FKBP12.6 (12.6 kDa FK506-binding protein) from the channel, causing abnormal channel activation...
5.
Xiao J, Tian X, Jones P, Bolstad J, Kong H, Wang R, et al.
J Biol Chem
. 2007 Oct;
282(48):34828-38.
PMID: 17921453
The 12.6-kDa FK506-binding protein (FKBP12.6) is considered to be a key regulator of the cardiac ryanodine receptor (RyR2), but its precise role in RyR2 function is complex and controversial. In...
6.
Meng X, Xiao B, Cai S, Huang X, Li F, Bolstad J, et al.
J Biol Chem
. 2007 Jul;
282(35):25929-39.
PMID: 17606610
Type 2 ryanodine receptor (RyR2) is the major calcium release channel in cardiac muscle. Phosphorylation of RyR2 by cAMP-dependent protein kinase A and by calmodulin-dependent protein kinase II modulates channel...
7.
Wang R, Chen W, Cai S, Zhang J, Bolstad J, Wagenknecht T, et al.
J Biol Chem
. 2007 Apr;
282(24):17785-93.
PMID: 17452324
A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH(2)-terminal mutations associated with cardiac arrhythmias and sudden death. To...
8.
Hunt D, Jones P, Wang R, Chen W, Bolstad J, Chen K, et al.
Biochem J
. 2007 Feb;
404(3):431-8.
PMID: 17313373
K201 (JTV519), a benzothiazepine derivative, has been shown to possess anti-arrhythmic and cardioprotective properties, but the mechanism of its action is both complex and controversial. It is believed to stabilize...
9.
Wang R, Bolstad J, Kong H, Zhang L, Brown C, Chen S
J Biol Chem
. 2003 Nov;
279(5):3635-42.
PMID: 14593104
The predicted TM10 transmembrane sequence, (4844)IIFDITFFFFVIVILLAIIQGLII(4867), has been proposed to be the pore inner helix of the ryanodine receptor (RyR) and to play a crucial role in channel activation and...
10.
Wang R, Zhang L, Bolstad J, Diao N, Brown C, Ruest L, et al.
J Biol Chem
. 2003 Oct;
278(51):51557-65.
PMID: 14557272
Despite the pivotal role of ryanodine in ryanodine receptor (RyR) research, the molecular basis of ryanodine-RyR interaction remains largely undefined. We investigated the role of the proposed transmembrane helix TM10...