Jeeva Munasinghe
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Explore the profile of Jeeva Munasinghe including associated specialties, affiliations and a list of published articles.
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47
Citations
1386
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Recent Articles
1.
Rosenblum J, Cole Y, Dang D, Lookian P, Alkaissi H, Patel M, et al.
JNCI Cancer Spectr
. 2025 Jan;
9(1).
PMID: 39821441
Background: Head and neck paragangliomas (HNPGLs) are typically slow-growing, hormonally inactive tumors of parasympathetic paraganglia. Inactivation of prolyl-hydroxylase domain-containing 2 protein causing indirect gain-of-function of hypoxia-inducible factor-2α (HIF-2α), encoded by...
2.
Yoshida T, Yang Z, Ashida S, Yu Z, Shrivastav S, Rojulpote K, et al.
bioRxiv
. 2025 Jan;
PMID: 39803526
Introduction: In USA, six million individuals with Sub-Saharan ancestry carry two high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants are independent risk factors for cardiovascular...
3.
Nicoli E, Huebecker M, Han S, Garcia K, Munasinghe J, Lizak M, et al.
Mol Genet Metab
. 2023 Jan;
138(2):107508.
PMID: 36709532
GM1 gangliosidosis is a rare lysosomal storage disorder affecting multiple organ systems, primarily the central nervous system, and is caused by functional deficiency of β-galactosidase (GLB1). Using CRISPR/Cas9 genome editing,...
4.
Shuboni-Mulligan D, Young Jr D, De La Cruz Minyety J, Briceno N, Celiku O, King A, et al.
Sci Rep
. 2022 Jul;
12(1):11131.
PMID: 35778467
Disrupted sleep, including daytime hypersomnolence, is a core symptom reported by primary brain tumor patients and often manifests after radiotherapy. The biological mechanisms driving the onset of sleep disturbances after...
5.
Sanchez V, Lynes J, Walbridge S, Wang X, Edwards N, Nwankwo A, et al.
Sci Rep
. 2022 Apr;
12(1):5615.
PMID: 35379872
No abstract available.
6.
Shuboni-Mulligan D, Young Jr D, De La Cruz Minyety J, Vera E, Munasinghe J, Gall A, et al.
NPJ Aging Mech Dis
. 2021 May;
7(1):10.
PMID: 33947857
Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep...
7.
Rosenblum J, Wang H, Dmitriev P, Cappadona A, Mastorakos P, Xu C, et al.
JCI Insight
. 2021 Jan;
6(5).
PMID: 33497361
Mutations in EPAS1, encoding hypoxia-inducible factor-2α (HIF-2α), were previously identified in a syndrome of multiple paragangliomas, somatostatinoma, and polycythemia. HIF-2α, when dimerized with HIF-1β, acts as an angiogenic transcription factor....
8.
Sanchez V, Lynes J, Walbridge S, Wang X, Edwards N, Nwankwo A, et al.
Sci Rep
. 2020 Jul;
10(1):11003.
PMID: 32620877
Preclinical models that reliably recapitulate the immunosuppressive properties of human gliomas are essential to assess immune-based therapies. GL261 murine glioma cells are widely used as a syngeneic animal model of...
9.
Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging
Zhou Z, Deng H, Yang W, Wang Z, Lin L, Munasinghe J, et al.
Nat Commun
. 2020 Jun;
11(1):3032.
PMID: 32541769
Tumor heterogeneity is one major reason for unpredictable therapeutic outcomes, while stratifying therapeutic responses at an early time may greatly benefit the better control of cancer. Here, we developed a...
10.
Ruiz-Rodado V, Malta T, Seki T, Lita A, Dowdy T, Celiku O, et al.
Neuro Oncol
. 2019 Oct;
22(4):480-492.
PMID: 31665443
Background: Early detection of increased aggressiveness of brain tumors is a major challenge in the field of neuro-oncology because of the inability of traditional imaging to uncover it. Isocitrate dehydrogenase...