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Jeanine Jochems

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Articles 13
Citations 422
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Recent Articles
1.
Denton C, Kowal-Bielecka O, Proudman S, Olesinska M, Worm M, Papa N, et al.
Rheumatology (Oxford) . 2025 Feb; PMID: 39909490
Objectives: The primary objective was the safety of subcutaneous immunoglobulin, IgPro20 (Hizentra, CSL Behring) in adults with diffuse cutaneous systemic sclerosis (dcSSc). Secondary objectives included pharmacokinetics and relative bioavailability of...
2.
Cooper M, Cherney D, Greene T, Heerspink H, Jardine M, Lewis J, et al.
J Am Soc Nephrol . 2024 Aug; 35(11):1546-1557. PMID: 39150859
No abstract available.
3.
Tortorici M, Lawo J, Weide R, Jochems J, Puli S, Hofmann J, et al.
Int Immunopharmacol . 2018 Nov; 66:119-126. PMID: 30447530
Purpose: Primary (PID) and secondary immune deficiencies (SID) represent diverse groups of diagnoses, yet both can be effectively treated with intravenous immunoglobulin (IVIG) replacement therapy. Guidelines for the use of...
4.
Jochems J, Teegarden S, Chen Y, Boulden J, Challis C, Ben-Dor G, et al.
Biol Psychiatry . 2014 Dec; 77(4):345-55. PMID: 25442004
Background: Acetylation of heat shock protein 90 (Hsp90) regulates downstream hormone signaling via the glucocorticoid receptor (GR), but the role of this molecular mechanism in stress homeostasis is poorly understood....
5.
Summers C, Hammons A, Arora J, Zhang S, Jochems J, Blair I, et al.
Eur J Pharmacol . 2014 Mar; 732:60-7. PMID: 24657277
EA.hy 926 cells grown under low folate conditions adopt a "pro-atherosclerotic" morphology and biochemical phenotype. Pharmacologically relevant doses of the antifolate drug methotrexate (MTX) were applied to EA.hy 926 cells...
6.
Jochems J, Boulden J, Lee B, Blendy J, Jarpe M, Mazitschek R, et al.
Neuropsychopharmacology . 2013 Aug; 39(2):389-400. PMID: 23954848
HDAC inhibitors have been reported to produce antidepressant and pro-cognitive effects in animal models, however, poor brain bioavailability or lack of isoform selectivity of current probes has limited our understanding...
7.
Hammons A, Summers C, Jochems J, Arora J, Zhang S, Blair I, et al.
Eur J Pharmacol . 2012 Sep; 696(1-3):12-7. PMID: 22975265
Elevated homocysteine is a risk marker for several major human pathologies. Emerging evidence suggests that perturbations of folate/homocysteine metabolism can directly modify production of inflammatory mediators. Pemetrexed acts by inhibiting...
8.
Espallergues J, Teegarden S, Veerakumar A, Boulden J, Challis C, Jochems J, et al.
J Neurosci . 2012 Mar; 32(13):4400-16. PMID: 22457490
Genetic variations in certain components of the glucocorticoid receptor (GR) chaperone complex have been associated with the development of stress-related affective disorders and individual variability in therapeutic responses to antidepressants....
9.
Bell T, Miyashiro K, Sul J, Buckley P, Lee M, McCullough R, et al.
Proc Natl Acad Sci U S A . 2010 Nov; 107(49):21152-7. PMID: 21078998
We report that the stress axis-regulated exon (STREX)-containing calcium-activated big potassium (BKCa) channel splice variant expression and physiology are regulated in part by cytoplasmic splicing and intron retention. NextGen sequencing...
10.
Levin M, Lu M, Petrenko N, Hawkins B, Gupta T, Lang D, et al.
J Clin Invest . 2009 Oct; 119(11):3420-36. PMID: 19855129
Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic beats arising from the pulmonary veins and atrium, but the source and mechanism of these...