Jean Paul Chadarevian
Overview
Explore the profile of Jean Paul Chadarevian including associated specialties, affiliations and a list of published articles.
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20
Citations
376
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Recent Articles
1.
Granzotto A, McQuade A, Chadarevian J, Davtyan H, Sensi S, Parker I, et al.
Cell Calcium
. 2024 Jul;
123:102923.
PMID: 38970922
The central nervous system (CNS) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal...
2.
Rosenzweig N, Kleemann K, Rust T, Carpenter M, Grucci M, Aronchik M, et al.
Nat Med
. 2024 Jul;
30(10):2990-3003.
PMID: 38961225
APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell...
3.
Hovakimyan A, Chilingaryan G, King O, Capocchi J, Chadarevian J, Davtyan H, et al.
Vaccines (Basel)
. 2024 Jun;
12(6).
PMID: 38932388
The escalating global healthcare challenge posed by Alzheimer's Disease (AD) and compounded by the lack of effective treatments emphasizes the urgent need for innovative approaches to combat this devastating disease....
4.
Chadarevian J, Hasselmann J, Lahian A, Capocchi J, Escobar A, Lim T, et al.
Neuron
. 2024 Jun;
112(16):2686-2707.e8.
PMID: 38897209
Microglia replacement strategies are increasingly being considered for the treatment of primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). However, available mouse models fail to recapitulate...
5.
Munro D, Bestard-Cuche N, McQuaid C, Chagnot A, Kiani Shabestari S, Chadarevian J, et al.
Neuron
. 2024 Jun;
112(16):2732-2748.e8.
PMID: 38897208
Microglia are brain-resident macrophages that contribute to central nervous system (CNS) development, maturation, and preservation. Here, we examine the consequences of permanent microglial deficiencies on brain aging using the Csf1r...
6.
Granzotto A, McQuade A, Chadarevian J, Davtyan H, Sensi S, Parker I, et al.
bioRxiv
. 2024 Jan;
PMID: 38293075
The central nervous system (CNS) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal...
7.
Chadarevian J, Davtyan H, Lombroso S, Bennett F, Blurton-Jones M
STAR Protoc
. 2023 Jul;
4(3):102490.
PMID: 37516973
Chimeric mouse models have recently been developed to study human microglia in vivo. However, widespread engraftment of donor microglia within the adult brain has been challenging. Here, we present a...
8.
Zagorski K, King O, Hovakimyan A, Petrushina I, Antonyan T, Chailyan G, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37372944
Post-translationally modified N-terminally truncated amyloid beta peptide with a cyclized form of glutamate at position 3 (pEAβ) is a highly pathogenic molecule with increased neurotoxicity and propensity for aggregation. In...
9.
McQuade A, Kang Y, Hasselmann J, Jairaman A, Sotelo A, Coburn M, et al.
Nat Commun
. 2023 Mar;
14(1):1194.
PMID: 36864071
No abstract available.
10.
Chadarevian J, Lombroso S, Peet G, Hasselmann J, Tu C, Marzan D, et al.
J Exp Med
. 2022 Dec;
220(3).
PMID: 36584406
Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and expand the potential for microglia replacement, we...