Jean-Luc Van Laethem
Overview
Explore the profile of Jean-Luc Van Laethem including associated specialties, affiliations and a list of published articles.
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128
Citations
5117
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Recent Articles
1.
Gallois C, Sroussi M, Andre T, Mouillet-Richard S, Agueeff N, Mulot C, et al.
J Clin Oncol
. 2025 Jan;
:JCO2302262.
PMID: 39889251
Purpose: The objective of this work was to establish prognostic models in stage III colon cancer (CC) on the basis of transcriptomic signatures of the tumor microenvironment (TME) and cell...
2.
Islam O, Islam O, Sarti K, Sarti K, Verbruggen L, Verbruggen L, et al.
Endocr Relat Cancer
. 2025 Jan;
32(4).
PMID: 39888333
Gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) exhibit substantial biological heterogeneity, impacting clinical management and outcomes. In 2019, the WHO subdivided the grade 3 (G3) neuroendocrine neoplasms (NEN) characterised by Ki-67 >...
3.
Navez J, Pezzullo M, Bouchart C, Arsenijevic T, Demetter P, Closset J, et al.
BJS Open
. 2024 Nov;
8(6).
PMID: 39601263
Background: The most frequently invaded margins on pancreatoduodenectomy specimens for pancreatic ductal adenocarcinoma are vascular margins, particularly the superior mesenteric artery (or mesopancreatic) margin. Due to limited exploration of the...
4.
Libert M, Quiquempoix S, Fain J, Pyr Dit Ruys S, Haidar M, Wulleman M, et al.
EMBO Rep
. 2024 Oct;
25(11):4693-4707.
PMID: 39390257
Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation, and the aberrant assembly...
5.
Saude-Conde R, El Ghali B, Navez J, Bouchart C, Van Laethem J
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001485
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge in oncology due to its advanced stage upon diagnosis and limited treatment options. Surgical resection, the primary curative approach, often results in...
6.
Van Laethem J, Borbath I, Prenen H, Geboes K, Lambert A, Mitry E, et al.
Lancet Oncol
. 2024 Jun;
25(7):853-864.
PMID: 38834087
Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour...
7.
Mokhtari A, Casale R, Salahuddin Z, Paquier Z, Guiot T, Woodruff H, et al.
Diagnostics (Basel)
. 2024 Apr;
14(7).
PMID: 38611625
Purpose: This multicenter retrospective study aims to identify reliable clinical and radiomic features to build machine learning models that predict progression-free survival (PFS) and overall survival (OS) in pancreatic ductal...
8.
Saude-Conde R, Arcay Ozturk A, Stosic K, Azurmendi Senar O, Navez J, Bouchart C, et al.
Biomedicines
. 2024 Mar;
12(3).
PMID: 38540204
Pancreatic ductal adenocarcinoma (PDAC) represents a formidable challenge due to its aggressive nature and poor prognosis. The tumor microenvironment (TME) in PDAC, characterized by intense stromal desmoplastic reactions and a...
9.
Moreau M, Alouani E, Flecchia C, Falcoz A, Gallois C, Auclin E, et al.
Eur J Cancer
. 2024 Mar;
202:114033.
PMID: 38537314
Background: One randomized phase III trial comparing chemotherapy (CT) with immune checkpoint inhibitors (ICI) has demonstrated significant efficacy of ICI in deficient DNA mismatch repair system/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal...
10.
Stosic K, Azurmendi Senar O, Tarfouss J, Bouchart C, Navez J, Van Laethem J, et al.
Cells
. 2024 Jan;
13(1).
PMID: 38201207
Pancreatic ductal adenocarcinoma is one of the most lethal malignant diseases, with a mortality rate being close to incidence. Due to its heterogeneity and plasticity, as well as the lack...