Jean-Frederic Gerbeau
Overview
Explore the profile of Jean-Frederic Gerbeau including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
165
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Recent Articles
1.
Raphel F, de Korte T, Lombardi D, Braam S, Gerbeau J
PLoS Comput Biol
. 2020 Sep;
16(9):e1008203.
PMID: 32976482
Novel studies conducting cardiac safety assessment using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising but might be limited by their specificity and predictivity. It is often challenging to correctly...
2.
Ratelade J, Klug N, Lombardi D, Angelim M, Dabertrand F, Domenga-Denier V, et al.
Circulation
. 2020 Mar;
141(25):2078-2094.
PMID: 32183562
Background: Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the site of arteriolar...
3.
This A, Boilevin-Kayl L, Fernandez M, Gerbeau J
Int J Numer Method Biomed Eng
. 2019 Jun;
36(3):e3223.
PMID: 31206245
In order to reduce the complexity of heart hemodynamics simulations, uncoupling approaches are often considered for the modeling of the immersed valves as an alternative to complex fluid-structure interaction (FSI)...
4.
Gerbeau J, Lombardi D, Tixier E
Math Biosci
. 2018 Jul;
303:62-74.
PMID: 29959949
In numerous applications in biophysics, physiology and medicine, the system of interest is studied by monitoring quantities, called biomarkers, extracted from measurements. These biomarkers convey some information about relevant hidden...
5.
Tixier E, Raphel F, Lombardi D, Gerbeau J
Front Physiol
. 2018 Jan;
8:1096.
PMID: 29354067
The Micro-Electrode Array (MEA) device enables high-throughput electrophysiology measurements that are less labor-intensive than patch-clamp based techniques. Combined with human-induced pluripotent stem cells cardiomyocytes (hiPSC-CM), it represents a new and...
6.
Abbate E, Boulakia M, Coudiere Y, Gerbeau J, Zitoun P, Zemzemi N
J Pharmacol Toxicol Methods
. 2017 Oct;
89:59-72.
PMID: 29066291
We propose a mathematical approach for the analysis of drugs effects on the electrical activity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) based on multi-electrode array (MEA) experiments. Our...
7.
Raphel F, Boulakia M, Zemzemi N, Coudiere Y, Guillon J, Zitoun P, et al.
IEEE Trans Biomed Eng
. 2017 Sep;
65(6):1311-1319.
PMID: 28880155
Objective: Multi electrodes arrays (MEAs) combined with cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) can enable high- or medium-throughput drug screening in safety pharmacology. This technology has recently attracted...
8.
Tixier E, Lombardi D, Rodriguez B, Gerbeau J
J R Soc Interface
. 2017 Aug;
14(133).
PMID: 28835541
The variability observed in action potential (AP) cardiomyocyte measurements is the consequence of many different sources of randomness. Often ignored, this variability may be studied to gain insight into the...
9.
Cavero I, Guillon J, Ballet V, Clements M, Gerbeau J, Holzgrefe H
J Pharmacol Toxicol Methods
. 2016 May;
81:21-36.
PMID: 27233533
Introduction: The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a nonclinical Safety Pharmacology paradigm for discovering electrophysiological mechanisms that are likely to confer proarrhythmic liability to drug candidates intended for...
10.
Schenone E, Collin A, Gerbeau J
Int J Numer Method Biomed Eng
. 2015 Aug;
32(5).
PMID: 26249327
This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic...