Jean-Francois Griffon
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Explore the profile of Jean-Francois Griffon including associated specialties, affiliations and a list of published articles.
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6
Citations
12
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Recent Articles
1.
Alexandre F, Badaroux E, Bilello J, Bot S, Bouisset T, Brandt G, et al.
Bioorg Med Chem Lett
. 2017 Aug;
27(18):4323-4330.
PMID: 28835346
Herein we describe the discovery of IDX21437 35b, a novel Rd-aminoacid-based phosphoramidate prodrug of 2'-α-chloro-2'-β-C-methyluridine monophosphate. Its corresponding triphosphate 6 is a potent inhibitor of the HCV NS5B RNA-dependent RNA...
2.
Paparin J, Amador A, Badaroux E, Bot S, Caillet C, Convard T, et al.
Bioorg Med Chem Lett
. 2017 Apr;
27(11):2634-2640.
PMID: 28416131
Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells, and as a consequence is an...
3.
Pierra Rouviere C, Amador A, Badaroux E, Convard T, Costa D, Dukhan D, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(18):4536-4541.
PMID: 27520942
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is...
4.
Griffon J, Dumas A, Storer R, Sommadossi J, Gosselin G
Nucleosides Nucleotides Nucleic Acids
. 2010 Feb;
28(5):435-49.
PMID: 20183594
In the search for inhibitors of the replication of RNA viruses, including hepatitis C virus (HCV), the hitherto unknown 4'-C-azidomethyl-beta-D-ribofuranosyl nucleosides of the five naturally occurring nucleic acid bases have...
5.
Sizun G, Dukhan D, Griffon J, Griffe L, Meillon J, Leroy F, et al.
Carbohydr Res
. 2009 Jan;
344(4):448-53.
PMID: 19147123
The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as a seven-membered ring sugar moiety, namely 9-(5-deoxy-beta-D-allo-septanosyl)-adenine, is reported. This compound was synthesized in 14 steps from the commercially...
6.
Sizun G, Griffon J, Griffe L, Dukhan D, Storer R, Sommadossi J, et al.
Nucleic Acids Symp Ser (Oxf)
. 2008 Sep;
(52):611-2.
PMID: 18776528
The first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as the sugar moiety was synthesized and evaluated as a potential inhibitor of several virus replication.