Jaycob D Warfel
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Explore the profile of Jaycob D Warfel including associated specialties, affiliations and a list of published articles.
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10
Citations
193
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Recent Articles
1.
Noland R, Ghosh S, Crisanto C, Aleman A, Chaney M, Chauhan M, et al.
Front Physiol
. 2025 Mar;
15:1468369.
PMID: 40046510
Introduction: Metabolic flexibility is the ability of a system to switch between metabolic substrates. Human and murine skeletal muscle tissues and cells with decreased activity of the regulatory RNA-binding protein,...
2.
Warfel J, Elks C, Bayless D, Vandanmagsar B, Stone A, Velasquez S, et al.
Acta Physiol (Oxf)
. 2023 Jan;
238(1):e13935.
PMID: 36650072
Aim: Valuable studies have tested the role of UCP1 on body temperature maintenance in mice, and we sought to knockout Ucp1 in rats (Ucp1 ) to provide insight into thermogenic...
3.
Mynatt R, Noland R, Elks C, Vandanmagsar B, Bayless D, Stone A, et al.
Metabolism
. 2022 Nov;
138:155345.
PMID: 36410080
No abstract available.
4.
Stone A, Noland R, Mynatt R, Velasquez S, Bayless D, Ravussin E, et al.
Biology (Basel)
. 2021 Jul;
10(6).
PMID: 34204316
Male mice lacking HuR in skeletal muscle (HuR) have been shown to have decreased gastrocnemius lipid oxidation and increased adiposity and insulin resistance. The same consequences have not been documented...
5.
Mynatt R, Noland R, Elks C, Vandanmagsar B, Bayless D, Stone A, et al.
Metabolism
. 2019 May;
97:40-49.
PMID: 31129047
Background: Metabolic flexibility can be assessed by changes in respiratory exchange ratio (RER) following feeding. Though metabolic flexibility (difference in RER between fasted and fed state) is often impaired in...
6.
Warfel J, Vandanmagsar B, Wicks S, Zhang J, Noland R, Mynatt R
PLoS One
. 2017 Dec;
12(12):e0188850.
PMID: 29240830
Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1bm-/-) comprise a model of impaired fat oxidation; and...
7.
Warfel J, Vandanmagsar B, Dubuisson O, Hodgeson S, Elks C, Ravussin E, et al.
Am J Physiol Regul Integr Comp Physiol
. 2017 Mar;
312(5):R816-R820.
PMID: 28330968
Carnitine palmitoyltransferase 1 (CPT1) is essential for the transport of long-chain fatty acids into the mitochondria for oxidation. Recently, it was reported that decreased CPT1b mRNA in adipose tissue was...
8.
Warfel J, Bermudez E, Mendoza T, Ghosh S, Zhang J, Elks C, et al.
Sci Rep
. 2016 Nov;
6:37941.
PMID: 27892502
Inflammation, lipotoxicity and mitochondrial dysfunction have been implicated in the pathogenesis of obesity-induced insulin resistance and type 2 diabetes. However, how these factors are intertwined in the development of obesity/insulin...
9.
Vandanmagsar B, Warfel J, Wicks S, Ghosh S, Salbaum J, Burk D, et al.
Cell Rep
. 2016 May;
15(8):1686-99.
PMID: 27184848
Fatty acids are the primary fuel source for skeletal muscle during most of our daily activities, and impaired fatty acid oxidation (FAO) is associated with insulin resistance. We have developed...
10.
Wicks S, Vandanmagsar B, Haynie K, Fuller S, Warfel J, Stephens J, et al.
Proc Natl Acad Sci U S A
. 2015 Jun;
112(25):E3300-9.
PMID: 26056297
The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle...