Jayasankar Jasti
Overview
Explore the profile of Jayasankar Jasti including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
741
Followers
0
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Recent Articles
1.
de Monerri N, Che Y, Lees J, Jasti J, Wu H, Griffor M, et al.
PLoS Pathog
. 2025 Feb;
21(2):e1012325.
PMID: 39970181
Adhesion of E. coli to the urinary tract epithelium is a critical step in establishing urinary tract infections. FimH is an adhesin positioned on the fimbrial tip which binds to...
2.
Knee K, Jasuja R, Barakat A, Rao D, Wenzel Z, Jasti J, et al.
Am J Hematol
. 2021 Apr;
96(8):E272-E275.
PMID: 33891711
No abstract available.
3.
Gopalsamy A, Aulabaugh A, Barakat A, Beaumont K, Cabral S, Canterbury D, et al.
J Med Chem
. 2020 Dec;
64(1):326-342.
PMID: 33356244
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin...
4.
Futatsugi K, Smith A, Tu M, Raymer B, Ahn K, Coffey S, et al.
J Med Chem
. 2020 Sep;
63(22):13546-13560.
PMID: 32910646
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to...
5.
Lovering F, Morgan P, Allais C, Aulabaugh A, Brodfuehrer J, Chang J, et al.
Eur J Med Chem
. 2018 Jan;
145:606-621.
PMID: 29348070
Many diseases are believed to be driven by pathological levels of reactive oxygen species (ROS) and oxidative stress has long been recognized as a driver for inflammatory disorders. Apoptosis signal-regulating...
6.
Henderson J, Kormos B, Hayward M, Coffman K, Jasti J, Kurumbail R, et al.
J Med Chem
. 2014 Oct;
58(1):419-32.
PMID: 25353650
Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in...
7.
Jasti J, Furukawa H, Gonzales E, Gouaux E
Nature
. 2007 Sep;
449(7160):316-23.
PMID: 17882215
Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in perception of pain, ischaemic stroke, mechanosensation, learning...
8.
Jabeen T, Singh N, Singh R, Jasti J, Sharma S, Kaur P, et al.
Proteins
. 2005 Nov;
62(2):329-37.
PMID: 16287060
The crystal structure of the phospholipase A2 (PLA2) heterodimer from Naja naja sagittifera reveals the presence of a new PLA2-like protein with eight disulphide bridges. The heterodimer is formed between...
9.
Singh G, Jasti J, Saravanan K, Sharma S, Kaur P, Srinivasan A, et al.
Protein Sci
. 2005 Jan;
14(2):395-400.
PMID: 15659372
This is the first evidence of a naturally bound fatty acid to a group I Phospholipase A(2) (PLA(2)) and also to a PLA(2) with Asp 49. The fatty acid identified...
10.
Jasti J, Paramasivam M, Srinivasan A, Singh T
Acta Crystallogr D Biol Crystallogr
. 2003 Dec;
60(Pt 1):66-72.
PMID: 14684894
The crystal structure of an acidic phospholipase A(2) from the venom of Echis carinatus (saw-scaled viper; scPLA(2)) has been determined at 2.6 A resolution and refined to a crystallographic R...