Jay Prakash Jain
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Explore the profile of Jay Prakash Jain including associated specialties, affiliations and a list of published articles.
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23
Citations
349
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Recent Articles
1.
Gal I, Demarta-Gatsi C, Fontinha D, Arez F, Wicha S, Rottmann M, et al.
ACS Infect Dis
. 2024 Dec;
11(1):69-79.
PMID: 39657997
New antimalarial combination therapies with novel modes of action are required to counter the emergence and spread of drug resistance against existing therapeutics. Here, we present a study to evaluate...
2.
Taft B, Yokokawa F, Kirrane T, Mata A, Huang R, Blaquiere N, et al.
J Med Chem
. 2022 Mar;
65(5):3798-3813.
PMID: 35229610
A series of 5-aryl-2-amino-midazohiaiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage () growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency,...
3.
Ndayisaba G, Yeka A, Asante K, Grobusch M, Karita E, Mugerwa H, et al.
Malar J
. 2021 Dec;
20(1):478.
PMID: 34930267
Background: The novel anti-malarial cipargamin (KAE609) has potent, rapid activity against Plasmodium falciparum. Transient asymptomatic liver function test elevations were previously observed in cipargamin-treated subjects in two trials: one in...
4.
Kublin J, Murphy S, Maenza J, Seilie A, Jain J, Berger D, et al.
Clin Infect Dis
. 2020 Jul;
73(7):e2407-e2414.
PMID: 32644127
Background: KAF156 is a novel antimalarial drug that is active against both liver- and blood-stage Plasmodium parasites, including drug-resistant strains. Here, we investigated the causal prophylactic efficacy of KAF156 in...
5.
Leong F, Jain J, Feng Y, Goswami B, Stein D
Malar J
. 2018 Jan;
17(1):7.
PMID: 29304859
Background: KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for...
6.
Jain J, Leong F, Chen L, Kalluri S, Koradia V, Stein D, et al.
Antimicrob Agents Chemother
. 2017 Jun;
61(9).
PMID: 28630183
The artemether-lumefantrine combination requires food intake for the optimal absorption of lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid dispersion formulations (SDF) were developed, and the...
7.
Hien T, White N, Thuy-Nhien N, Hoa N, Thuan P, Tarning J, et al.
Antimicrob Agents Chemother
. 2016 Nov;
61(2).
PMID: 27872070
The MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure the cure...
8.
Lin W, Heimbach T, Jain J, Awasthi R, Hamed K, Sunkara G, et al.
J Pharm Sci
. 2016 Aug;
105(10):3205-3213.
PMID: 27506269
Artemether is co-administered with lumefantrine as part of a fixed-dose combination therapy for malaria in both adult and pediatric patients. However, artemether exposure is higher in younger infants (1-3 months)...
9.
Tiono A, Tinto H, Alao M, Meremikwu M, Tshefu A, Ogutu B, et al.
Malar J
. 2015 Apr;
14:157.
PMID: 25886021
Background: Artemether-lumefantrine (AL) dispersible formulation was developed for the treatment of uncomplicated Plasmodium falciparum malaria in infants and children weighing 5 to <35 kg. However, there are no clinical studies...
10.
Stein D, Jain J, Kangas M, Lefevre G, Machineni S, Griffin P, et al.
Antimicrob Agents Chemother
. 2015 Apr;
59(6):3493-500.
PMID: 25845867
KAE609 represents a new class of potent, fast-acting, schizonticidal antimalarials. This study investigated the safety and pharmacokinetics of KAE609 in combination with the long-acting antimalarial piperaquine (PPQ) in healthy volunteers....