Jay D Keasling
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Explore the profile of Jay D Keasling including associated specialties, affiliations and a list of published articles.
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465
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17440
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Recent Articles
11.
Liu Y, Zhao X, Gan F, Chen X, Deng K, Crowe S, et al.
Nature
. 2024 May;
629(8013):937-944.
PMID: 38720067
QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans. However, owing to the complex structure of QS-21, its...
12.
Cano-Prieto C, Undabarrena A, Calheiros de Carvalho A, Keasling J, Cruz-Morales P
Annu Rev Biochem
. 2024 Apr;
93(1):411-445.
PMID: 38639989
Natural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification and biosynthetic origins, and...
13.
Bradley S, Hansson F, Lehka B, Rago D, Pinho P, Peng H, et al.
ACS Synth Biol
. 2024 Apr;
13(5):1498-1512.
PMID: 38635307
Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a stereochemically complex subclass with...
14.
Wang X, Chen N, Cruz-Morales P, Zhong B, Zhang Y, Wang J, et al.
Nat Metab
. 2024 Apr;
6(5):933-946.
PMID: 38609677
Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have...
15.
Maini Rekdal V, van der Luijt C, Chen Y, Kakumanu R, Baidoo E, Petzold C, et al.
Nat Commun
. 2024 Mar;
15(1):2099.
PMID: 38485948
Filamentous fungi are critical in the transition to a more sustainable food system. While genetic modification of these organisms has promise for enhancing the nutritional value, sensory appeal, and scalability...
16.
Crowe S, Zhao X, Gan F, Chen X, Hudson G, Astolfi M, et al.
ACS Synth Biol
. 2024 Mar;
13(4):1215-1224.
PMID: 38467016
Glycosylation of biomolecules can greatly alter their physicochemical properties, cellular recognition, subcellular localization, and immunogenicity. Glycosylation reactions rely on the stepwise addition of sugars using nucleotide diphosphate (NDP)-sugars. Making these...
17.
Petersen S, Levassor L, Pedersen C, Madsen J, Hansen L, Zhang J, et al.
PLoS Comput Biol
. 2024 Mar;
20(3):e1011929.
PMID: 38457467
Synthetic biology dictates the data-driven engineering of biocatalysis, cellular functions, and organism behavior. Integral to synthetic biology is the aspiration to efficiently find, access, interoperate, and reuse high-quality data on...
18.
Deng H, Yu H, Deng Y, Qiu Y, Li F, Wang X, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(14):e2306935.
PMID: 38321783
The evolution of pathway enzymes enhances the biosynthesis of high-value chemicals, crucial for pharmaceutical, and agrochemical applications. However, unpredictable evolutionary landscapes of pathway genes often hinder successful evolution. Here, the...
19.
Roberts J, Nava A, Pearson A, Incha M, Valencia L, Ma M, et al.
PLoS Comput Biol
. 2024 Feb;
20(2):e1011171.
PMID: 38306398
Foldy is a cloud-based application that allows non-computational biologists to easily utilize advanced AI-based structural biology tools, including AlphaFold and DiffDock. With many deployment options, it can be employed by...
20.
Martin L, Kikuchi S, Rejzek M, Owen C, Reed J, Orme A, et al.
Nat Chem Biol
. 2024 Jan;
20(4):493-502.
PMID: 38278997
QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and...