Jay C Unkeless
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Explore the profile of Jay C Unkeless including associated specialties, affiliations and a list of published articles.
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13
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728
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Recent Articles
1.
Huang B, Zhao J, Li H, He K, Chen Y, Mayer L, et al.
Cancer Res
. 2019 Aug;
79(16):4305.
PMID: 31416849
No abstract available.
2.
Dahan S, Rabinowitz K, Martin A, Berin M, Unkeless J, Mayer L
Gastroenterology
. 2010 Nov;
140(2):550-9.
PMID: 21056041
Background & Aims: Interactions between lymphocytes and intestinal epithelial cells occur in the subepithelial space of the gastrointestinal tract. Normal human lamina propria lymphocytes (LPLs) induce differentiation of intestinal epithelial...
3.
Martin A, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless J, Davies T, et al.
J Immunol
. 2009 Aug;
183(5):3073-80.
PMID: 19675158
CCR7 is involved in the initiation of immune responses and has been recently implicated in the control of tolerance. To analyze the role of CCR7 in autoimmunity, we backcrossed CCR7(ko/ko)...
4.
Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, et al.
J Biol Chem
. 2009 Jul;
284(36):24006-16.
PMID: 19592489
Interleukin (IL)-23, a new member of the IL-12 family, plays a central role in the Th17 immune response and in autoimmune diseases. It is clear that activated macrophages and dendritic...
5.
Shang L, Thirunarayanan N, Viejo-Borbolla A, Martin A, Bogunovic M, Marchesi F, et al.
Gastroenterology
. 2009 Jun;
137(3):1006-18, 1018.e1-3.
PMID: 19501588
Background & Aims: Chemokines are small proteins that direct leukocyte trafficking under homeostatic and inflammatory conditions. We analyzed the differential expression of chemokines in distinct segments of the intestine and...
6.
Shang L, Fukata M, Thirunarayanan N, Martin A, Arnaboldi P, Maussang D, et al.
Gastroenterology
. 2008 Jun;
135(2):529-38.
PMID: 18522803
Background & Aims: Several lines of evidence support a role for Toll-like receptor (TLR) signaling to protect the intestine from pathogenic infection. We hypothesized that TLR signaling at the level...
7.
Gu Y, Yang J, Ouyang X, Liu W, Li H, Yang J, et al.
Eur J Immunol
. 2008 May;
38(7):1807-13.
PMID: 18506885
IL-17 and IL-22 are typical cytokines produced by the Th17 T cell subset, but it is unclear if Th17 cytokines can be produced by other cell types. We demonstrate that...
8.
Yang J, Yang M, Htut T, Ouyang X, Hanidu A, Li X, et al.
Eur J Immunol
. 2008 Apr;
38(5):1204-14.
PMID: 18412165
Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 to form IL-27 and with IL-12p35 to form IL-35. IL-27Ralpha(-/-) mice studies indicate that IL-27 negatively regulates Th17 cell differentiation. However, no...
9.
Huang B, Zhao J, Li H, He K, Chen Y, Chen S, et al.
Cancer Res
. 2005 Jun;
65(12):5009-14.
PMID: 15958541
The signal pathways that trigger tumor cell escape from immune surveillance are incompletely understood. Toll-like receptors (TLRs), which activate innate and adaptive immune responses, are thought to be restricted to...
10.
Xiong H, Li H, Kong H, Chen Y, Zhao J, Xiong S, et al.
J Biol Chem
. 2005 Apr;
280(25):23531-9.
PMID: 15837792
Interferon regulatory factor (IRF)-8/interferon consensus sequence-binding protein is regulated by both transcription and degradation. IRF-8 induced in peritoneal macrophages by interferon-gamma and lipopolysaccharide was degraded rapidly, and degradation of IRF-8...