Javier Macias-Leon
Overview
Explore the profile of Javier Macias-Leon including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
101
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0
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Recent Articles
1.
Zeballos N, Gines-Alcober I, Macias-Leon J, Andres-Sanz D, Gonzalez-Ramirez A, Sanchez-Costa M, et al.
Protein Sci
. 2025 Jan;
34(2):e70040.
PMID: 39840824
Enzyme immobilization is indispensable for enhancing enzyme performance in various industrial applications. Typically, enzymes require specific spatial arrangements for optimal functionality, underscoring the importance of correct orientation. Despite well-known N-...
2.
Redrado-Hernandez S, Macias-Leon J, Castro-Lopez J, Sanz A, Dolader E, Arias M, et al.
Angew Chem Int Ed Engl
. 2024 Jun;
63(34):e202405823.
PMID: 38856634
Invasive fungal disease accounts for about 3.8 million deaths annually, an unacceptable rate that urgently prompts the discovery of new knowledge-driven treatments. We report the use of camelid single-domain nanobodies...
3.
Piniello B, Macias-Leon J, Miyazaki S, Garcia-Garcia A, Companon I, Ghirardello M, et al.
Nat Commun
. 2024 Feb;
15(1):1322.
PMID: 38351048
No abstract available.
4.
Piniello B, Macias-Leon J, Miyazaki S, Garcia-Garcia A, Companon I, Ghirardello M, et al.
Nat Commun
. 2023 Sep;
14(1):5785.
PMID: 37723184
Soluble HMW1C-like N-glycosyltransferases (NGTs) catalyze the glycosylation of Asn residues in proteins, a process fundamental for bacterial autoaggregation, adhesion and pathogenicity. However, our understanding of their molecular mechanisms is hindered...
5.
Villanueva-Saz S, Martinez M, Giner J, Gonzalez A, Tobajas A, Perez M, et al.
Vet Res Commun
. 2022 Oct;
47(2):615-629.
PMID: 36229725
Severe Acute Respiratory Syndrome Coronavirus 2 is the causative agent of Coronavirus Disease 2019 in humans. Among domestic animals, cats are more susceptible to SARS-CoV-2 than dogs. The detection of...
6.
Guerrero-Ochoa P, Ibanez-Perez R, Berbegal-Pinilla G, Aguilar D, Marzo I, Corzana F, et al.
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740244
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different...
7.
Villanueva-Saz S, Giner J, Fernandez A, Lacasta D, Ortin A, Ramos J, et al.
Animals (Basel)
. 2021 Aug;
11(7).
PMID: 34359111
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the zoonotic causative agent of coronavirus disease 2019 (COVID-19) that has caused a pandemic situation with millions of infected humans worldwide. Among...
8.
Santiago L, Uranga-Murillo I, Arias M, Gonzalez-Ramirez A, Macias-Leon J, Moreo E, et al.
Biology (Basel)
. 2021 Apr;
10(3).
PMID: 33801808
Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden. SARS-CoV-2, the causative agent of COVID-19, induces both...
9.
Villanueva-Saz S, Giner J, Tobajas A, Perez M, Gonzalez-Ramirez A, Macias-Leon J, et al.
Transbound Emerg Dis
. 2021 Mar;
69(3):1056-1064.
PMID: 33686768
A new coronavirus known as SARS-CoV-2 emerged in Wuhan in 2019 and spread rapidly to the rest of the world causing the pandemic disease named coronavirus disease of 2019 (COVID-19)....
10.
Macias-Leon J, Bermejo I, Asin A, Garcia-Garcia A, Companon I, Jimenez-Moreno E, et al.
Chem Commun (Camb)
. 2020 Nov;
56(96):15137-15140.
PMID: 33211039
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues,...