Jatta S Takkinen
Overview
Explore the profile of Jatta S Takkinen including associated specialties, affiliations and a list of published articles.
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7
Citations
98
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0
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Recent Articles
1.
Keller T, Lopez-Picon F, Krzyczmonik A, Forsback S, Takkinen J, Rajander J, et al.
J Cereb Blood Flow Metab
. 2019 May;
40(5):1012-1020.
PMID: 31142224
[F]F-DPA, a novel translocator protein 18 kDa (TSPO)-specific radioligand for imaging neuroinflammation, has to date been synthesized with low to moderate molar activities (A's). In certain cases, low A can...
2.
Snellman A, Takkinen J, Lopez-Picon F, Eskola O, Solin O, Rinne J, et al.
Sci Rep
. 2019 Apr;
9(1):5700.
PMID: 30952945
Back-translation of clinical imaging biomarkers of Alzheimer's disease (AD), such as alterations in cerebral glucose metabolism detected by [F]FDG positron emission tomography (PET), would be valuable for preclinical studies evaluating...
3.
Krzyczmonik A, Keller T, Lopez-Picon F, Forsback S, Kirjavainen A, Takkinen J, et al.
Mol Imaging Biol
. 2019 Feb;
21(5):879-887.
PMID: 30710261
Purpose: The α-adrenoceptors mediate many effects of norepinephrine and epinephrine, and participate in the regulation of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. Of the three receptor subtypes, only α...
4.
Lopez-Picon F, Kirjavainen A, Forsback S, Takkinen J, Peters D, Haaparanta-Solin M, et al.
Theranostics
. 2019 Jan;
9(1):11-19.
PMID: 30662550
Norepinephrine modulates cognitive processes such as working and episodic memory. Pathological changes in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the...
5.
Keller T, Lopez-Picon F, Krzyczmonik A, Forsback S, Kirjavainen A, Takkinen J, et al.
Nucl Med Biol
. 2018 Oct;
67:1-9.
PMID: 30317069
Introduction: Neuroinflammation is associated with several neurological disorders, including Alzheimer's disease (AD). The translocator protein 18 kDa (TSPO), due to its overexpression during microglial activation and relatively low levels in...
6.
Takkinen J, Lopez-Picon F, Kirjavainen A, Pihlaja R, Snellman A, Ishizu T, et al.
Neurobiol Aging
. 2018 Jun;
69:199-208.
PMID: 29909177
Contradictory findings on the role of the type 1 cannabinoid receptor (CBR) during the pathogenesis of Alzheimer's disease (AD) have been reported. Here, we evaluated the CBR brain profile in...
7.
Takkinen J, Lopez-Picon F, Al Majidi R, Eskola O, Krzyczmonik A, Keller T, et al.
J Cereb Blood Flow Metab
. 2016 Nov;
37(8):2870-2882.
PMID: 27834284
Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer's disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of...