Jason Younkin
Overview
Explore the profile of Jason Younkin including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
132
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0
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Recent Articles
1.
Jaster A, Younkin J, Cuddy T, de la Fuente Revenga M, Poklis J, Dozmorov M, et al.
Neurosci Lett
. 2022 Aug;
788:136836.
PMID: 35963476
Psychedelics, also known as classical hallucinogens, affect processes related to perception, cognition and sensory processing mostly via the serotonin 5-HT receptor (5-HTR). This class of psychoactive substances, which includes lysergic...
2.
Younkin J, Gaitonde S, Ellaithy A, Vekariya R, Baki L, Moreno J, et al.
ACS Chem Neurosci
. 2016 Jul;
7(9):1292-9.
PMID: 27385190
Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic...
3.
Baki L, Fribourg M, Younkin J, Eltit J, Moreno J, Park G, et al.
Pflugers Arch
. 2016 Jan;
468(5):775-93.
PMID: 26780666
We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011-1023, 2011)...
4.
Moreno J, Miranda-Azpiazu P, Garcia-Bea A, Younkin J, Cui M, Kozlenkov A, et al.
Sci Signal
. 2016 Jan;
9(410):ra5.
PMID: 26758213
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the pharmacology and functions of the constituent receptors. Previous findings demonstrated that the Gq/11-coupled...
5.
Ellaithy A, Younkin J, Gonzalez-Maeso J, Logothetis D
Trends Neurosci
. 2015 Jul;
38(8):506-16.
PMID: 26148747
The past two decades have witnessed a rise in the 'NMDA receptor hypofunction' hypothesis for schizophrenia, a devastating disorder that affects around 1% of the population worldwide. A variety of...
6.
Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, et al.
Curr Pharm Biotechnol
. 2014 Nov;
15(10):987-95.
PMID: 25374032
Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner....