Jason Shirian
Overview
Explore the profile of Jason Shirian including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
163
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Recent Articles
1.
Rotenberg N, Feldman M, Shirian J, Hockla A, Radisky E, Shifman J
J Biol Chem
. 2024 Oct;
300(11):107867.
PMID: 39419285
Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade extracellular matrix proteins, functioning in various physiological processes such as tissue remodeling, embryogenesis, and morphogenesis. Dysregulation of these enzymes is...
2.
Shirian J, Hockla A, Gleba J, Coban M, Rotenberg N, Strik L, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334953
Matrix metalloproteinases (MMPs) are significant drivers of many diseases, including cancer, and are established targets for drug development. Tissue inhibitors of metalloproteinases (TIMPs) are endogenous MMP inhibitors and are being...
3.
Shirian J, Hockla A, Gleba J, Coban M, Rotenberg N, Strik L, et al.
bioRxiv
. 2024 Jul;
PMID: 38979353
Matrix Metalloproteinases (MMPs) are drivers of many diseases including cancer and are established targets for drug development. Tissue inhibitors of metalloproteinases (TIMPs) are human proteins that inhibit MMPs and are...
4.
Heyne M, Shirian J, Cohen I, Peleg Y, Radisky E, Papo N, et al.
J Am Chem Soc
. 2021 Oct;
143(41):17261-17275.
PMID: 34609866
Protein-protein interactions (PPIs) have evolved to display binding affinities that can support their function. As such, cognate and noncognate PPIs could be highly similar structurally but exhibit huge differences in...
5.
Shirian J, Arkadash V, Cohen I, Sapir T, Radisky E, Papo N, et al.
FEBS Lett
. 2018 Feb;
592(7):1122-1134.
PMID: 29473954
MMP-14 and MMP-9 are two well-established cancer targets for which no specific clinically relevant inhibitor is available. Using a powerful combination of computational design and yeast surface display technology, we...
6.
Arkadash V, Yosef G, Shirian J, Cohen I, Horev Y, Grossman M, et al.
J Biol Chem
. 2017 Jan;
292(8):3481-3495.
PMID: 28087697
Degradation of the extracellular matrices in the human body is controlled by matrix metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in MMP activity can result in...
7.
Shirian J, Sharabi O, Shifman J
Trends Biochem Sci
. 2016 Aug;
41(9):739-745.
PMID: 27477052
Understanding the energetics and architecture of protein-binding interfaces is important for basic research and could potentially facilitate the design of novel binding domains for biotechnological applications. It is well accepted...
8.
Rosenfeld L, Shirian J, Zur Y, Levaot N, Shifman J, Papo N
J Biol Chem
. 2015 Sep;
290(43):26180-93.
PMID: 26359491
The molecular interactions between macrophage colony-stimulating factor (M-CSF) and the tyrosine kinase receptor c-FMS play a key role in the immune response, bone metabolism, and the development of some cancers....
9.
Sharabi O, Shirian J, Grossman M, Lebendiker M, Sagi I, Shifman J
PLoS One
. 2014 Apr;
9(4):e93712.
PMID: 24710006
Multispecific proteins play a major role in controlling various functions such as signaling, regulation of transcription/translation, and immune response. Hence, a thorough understanding of the atomic-level principles governing multispecific interactions...
10.
Aizner Y, Sharabi O, Shirian J, Dakwar G, Risman M, Avraham O, et al.
Structure
. 2014 Mar;
22(4):636-45.
PMID: 24613488
Our understanding of protein evolution would greatly benefit from mapping of binding landscapes, i.e., changes in protein-protein binding affinity due to all single mutations. However, experimental generation of such landscapes...