Jason R Thomas
Overview
Explore the profile of Jason R Thomas including associated specialties, affiliations and a list of published articles.
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37
Citations
1146
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Recent Articles
1.
Schroder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, et al.
Nat Commun
. 2024 Aug;
15(1):7109.
PMID: 39160182
No abstract available.
2.
Thomas J, Shelton 4th C, Murphy J, Brittain S, Bray M, Aspesi P, et al.
ACS Chem Biol
. 2024 Apr;
19(4):938-952.
PMID: 38565185
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression...
3.
Schroder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, et al.
Nat Commun
. 2024 Jan;
15(1):275.
PMID: 38177131
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a...
4.
Salvi A, Young A, Huntsman A, Pergande M, Korkmaz M, Rathnayake R, et al.
Cell Death Dis
. 2022 Jan;
13(1):45.
PMID: 35013112
PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo...
5.
Remillard D, Savage N, Kedves A, Paulk J, Chen X, Garcia F, et al.
ACS Chem Biol
. 2021 Sep;
16(11):2185-2192.
PMID: 34515462
Bromodomain-containing proteins frequently reside in multisubunit chromatin complexes with tissue or cell state-specific compositions. Recent studies have revealed tumor-specific dependencies on the BAF complex bromodomain subunit BRD9 that are a...
6.
Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, et al.
Nat Chem Biol
. 2021 Jan;
17(3):280-290.
PMID: 33462494
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal...
7.
Ross N, Lohmann F, Carbonneau S, Fazal A, Weihofen W, Gleim S, et al.
Nat Chem Biol
. 2020 Mar;
16(4):479.
PMID: 32139909
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Ross N, Lohmann F, Carbonneau S, Fazal A, Weihofen W, Gleim S, et al.
Nat Chem Biol
. 2019 Dec;
16(1):50-59.
PMID: 31819276
The post-genomic era has seen many advances in our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic...
9.
Farmer H, Wray L, Thomas J
Gerontol Geriatr Med
. 2019 Jul;
5:2333721419855665.
PMID: 31276018
Everyday discrimination is a potent source of stress for racial minorities, and is associated with a wide range of negative health outcomes, spanning both mental and physical health. Few studies...
10.
Spradlin J, Hu X, Ward C, Brittain S, Jones M, Ou L, et al.
Nat Chem Biol
. 2019 Jun;
15(7):747-755.
PMID: 31209351
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we...