Jason P Smith
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Explore the profile of Jason P Smith including associated specialties, affiliations and a list of published articles.
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49
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1550
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Recent Articles
1.
Egas Santander D, Pokorny C, Ecker A, Lazovskis J, Santoro M, Smith J, et al.
iScience
. 2025 Jan;
28(1):111585.
PMID: 39845419
We hypothesized that the heterogeneous architecture of biological neural networks provides a substrate to regulate the well-known tradeoff between robustness and efficiency, thereby allowing different subpopulations of the same network...
2.
Yamaguchi H, Guagliardo N, Smith J, Xu F, Yamaguchi M, Almeida L, et al.
bioRxiv
. 2025 Jan;
PMID: 39763801
Background: Juxtaglomerular (JG) cells are sensors that control blood pressure and fluid-electrolyte homeostasis. In response to a decrease in perfusion pressure or changes in the composition and/or volume of the...
3.
Anjum H, Smith J, Martini A, Yacu G, Medrano S, Gomez R, et al.
Am J Physiol Renal Physiol
. 2024 Nov;
328(1):F121-F130.
PMID: 39589156
Renin is crucial for blood pressure regulation and electrolyte balance, and its expressing cells arise from Forkhead box D1-positive (Foxd1) stromal progenitors. However, factors guiding these progenitors toward renin-secreting cell...
4.
Nagalakshmi V, Smith J, Matsuoka D, Gomez R, Sequeira-Lopez M
Clin Sci (Lond)
. 2024 Nov;
138(23):1527-1536.
PMID: 39564667
Renin-expressing juxtaglomerular (JG) cells possess an intrinsic pressure-sensing mechanism(s) that regulates renin synthesis and release in response to changes in perfusion pressure. Although we recently described the structure of the...
5.
Fung C, Alessi C, Martin J, Josephson K, Kierlin L, Dzierzewski J, et al.
JAMA Intern Med
. 2024 Oct;
184(12):1448-1456.
PMID: 39374004
Importance: Placebo effects are commonly observed in benzodiazepine receptor agonist hypnotic clinical trials. Clinical guidelines recommend discontinuing benzodiazepine receptor agonist hypnotics (particularly in older adults) and administering cognitive behavioral therapy...
6.
Yamaguchi M, Almeida L, Yamaguchi H, Liang X, Smith J, Medrano S, et al.
Circ Res
. 2024 Oct;
135(10):1025-1027.
PMID: 39351666
No abstract available.
7.
Medrano S, Yamaguchi M, Almeida L, Smith J, Yamaguchi H, Sigmund C, et al.
Am J Physiol Renal Physiol
. 2024 Jul;
327(3):F489-F503.
PMID: 38991008
Fate mapping and genetic manipulation of renin cells have relied on either noninducible lines that can introduce the developmental effects of gene deletion or bacterial artificial chromosome transgene-based inducible models...
8.
Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State
Smith J, Paxton R, Medrano S, Sheffield N, Sequeira-Lopez M, Gomez R
Hypertension
. 2024 Jul;
81(9):1869-1882.
PMID: 38989586
Background: Renin-expressing cells are myoendocrine cells crucial for the maintenance of homeostasis. Renin is regulated by cAMP, p300 (histone acetyltransferase p300)/CBP (CREB-binding protein), and Brd4 (bromodomain-containing protein 4) proteins and...
9.
LeRoy N, Smith J, Zheng G, Rymuza J, Gharavi E, Brown D, et al.
NAR Genom Bioinform
. 2024 Jul;
6(3):lqae073.
PMID: 38974799
Data from the single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) are now widely available. One major computational challenge is dealing with high dimensionality and inherent sparsity, which is typically...
10.
Anjum H, Smith J, Martini A, Yacu G, Medrano S, Gomez R, et al.
bioRxiv
. 2024 Apr;
PMID: 38585851
New & Noteworthy: This manuscript provides novel insights into the role of Tcf21 in the differentiation of Foxd1+ cells into JG cells. Utilizing integrated scRNA-seq and scATAC-seq, the study reveals...