Jason Newbern
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Explore the profile of Jason Newbern including associated specialties, affiliations and a list of published articles.
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340
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Recent Articles
1.
Lintecum K, Thumsi A, Dunn K, Druschel L, Chimene S, Prieto D, et al.
bioRxiv
. 2024 Dec;
PMID: 39677609
Teaser: In this study, a vaccine formulation was generated to develop central nervous specific immunosuppressive responses for TBI.
2.
Ortiz J, Newbern J, Conrad C
Hippocampus
. 2020 Nov;
31(2):221-231.
PMID: 33241879
Past studies find that chronic stress alters inhibitory, GABAergic circuitry of neurons in distinct hippocampal subregions. Less clear is whether these effects persist weeks after chronic stress ends, and whether...
3.
Bharadwaj V, Copeland C, Mathew E, Newbern J, Anderson T, Lifshitz J, et al.
Tissue Eng Part A
. 2020 Jul;
26(13-14):688-701.
PMID: 32697674
The development of effective therapeutics for brain disorders is challenging, in particular, the blood-brain barrier (BBB) severely limits access of the therapeutics into the brain parenchyma. Traumatic brain injury (TBI)...
4.
Hrach H, OBrien S, Steber H, Newbern J, Rawls A, Mangone M
Hum Mol Genet
. 2020 Apr;
29(10):1607-1623.
PMID: 32227114
Duchenne muscular dystrophy (DMD) is a lethal, X-linked disease characterized by progressive muscle degeneration. The condition is driven by nonsense and missense mutations in the dystrophin gene, leading to instability...
5.
Aoidi R, Houde N, Landry-Truchon K, Holter M, Jacquet K, Charron L, et al.
Dis Model Mech
. 2018 Mar;
11(3).
PMID: 29590634
The RAS/MAPK signaling pathway is one of the most investigated pathways, owing to its established role in numerous cellular processes and implication in cancer. Germline mutations in genes encoding members...
6.
Nichols J, Bjorklund G, Newbern J, Anderson T
J Physiol
. 2018 Jan;
596(7):1277-1293.
PMID: 29333742
Key Points: Traumatic brain injury (TBI) in children remains a leading cause of death and disability and it remains poorly understood why children have worse outcomes and longer recover times....
7.
Blazie S, Geissel H, Wilky H, Joshi R, Newbern J, Mangone M
Genetics
. 2017 Mar;
206(2):757-774.
PMID: 28348061
mRNA expression dynamics promote and maintain the identity of somatic tissues in living organisms; however, their impact in post-transcriptional gene regulation in these processes is not fully understood. Here, we...
8.
Newbern J, Birchmeier C
Semin Cell Dev Biol
. 2010 Sep;
21(9):922-8.
PMID: 20832498
Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation, migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of genetic models has unmasked...
9.
Newbern J, Zhong J, Wickramasinghe R, Li X, Wu Y, Samuels I, et al.
Proc Natl Acad Sci U S A
. 2008 Oct;
105(44):17115-20.
PMID: 18952847
Disrupted ERK1/2 (MAPK3/MAPK1) MAPK signaling has been associated with several developmental syndromes in humans; however, mutations in ERK1 or ERK2 have not been described. We demonstrate haplo-insufficient ERK2 expression in...
10.
Sun W, Gould T, Newbern J, Milligan C, Choi S, Kim H, et al.
J Neurosci
. 2005 Jun;
25(23):5595-603.
PMID: 15944387
c-Jun is a transcription factor that is involved in various cellular events, including apoptotic cell death. For example, phosphorylation of c-Jun is one of the earliest biochemical changes detected in...