Jason M Shohet
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Explore the profile of Jason M Shohet including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Zage P, Whittle S, Shohet J
J Cell Biochem
. 2016 Jul;
118(2):221-231.
PMID: 27428599
The neural crest is a population of cells in the vertebrate embryo that gives rise to a wide range of tissues and cell types, including components of the peripheral nervous...
12.
Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne P, Kim E, et al.
Oncotarget
. 2016 Mar;
7(17):24018-26.
PMID: 26993602
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with high mortality rates. The tyrosine kinase c-Src has been known to play an important role in differentiation of NB...
13.
Bogen D, Wei J, Azorsa D, Ormanoglu P, Buehler E, Guha R, et al.
Oncotarget
. 2015 Oct;
6(34):35247-62.
PMID: 26497213
Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to cope with long-term side effects from high-dose chemotherapy and radiation....
14.
Sun Y, Bell J, Carter D, Gherardi S, Poulos R, Milazzo G, et al.
Cancer Res
. 2015 Oct;
75(23):5143-54.
PMID: 26471359
MYCN gene amplification in neuroblastoma drives a gene expression program that correlates strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (H3K4) at target gene promoters is a...
15.
Kim E, Agarwal S, Shohet J
Cancer Res
. 2015 Sep;
75(18):3992.
PMID: 26337907
No abstract available.
16.
Zhang L, Agarwal S, Shohet J, Zage P
Anticancer Res
. 2015 Jul;
35(7):3787-92.
PMID: 26124323
Background/aim: Melanoma tumor cell sub-populations expressing a variety of specific molecular markers have been identified. We hypothesized that expression of CD114, the cell surface receptor for granulocyte-colony stimulating factor (G-CSF),...
17.
Beckers A, Van Peer G, Carter D, Gartlgruber M, Herrmann C, Agarwal S, et al.
Cancer Lett
. 2015 Jul;
366(1):123-32.
PMID: 26123663
LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN...
18.
Yang J, AlTahan A, Hu D, Wang Y, Cheng P, Morton C, et al.
J Natl Cancer Inst
. 2015 May;
107(6):djv080.
PMID: 25925418
Background: Epigenetic alterations, such as histone methylation, modulate Myc signaling, a pathway central to oncogenesis. We investigated the role of the histone demethylase KDM4B in N-Myc-mediated neuroblastoma pathogenesis. Methods: Spearman...
19.
Agarwal S, Lakoma A, Chen Z, Hicks J, Metelitsa L, Kim E, et al.
Cancer Res
. 2015 Apr;
75(12):2566-79.
PMID: 25908586
Increasing evidence suggests that inflammatory cytokines play a critical role in tumor initiation and progression. A cancer stem cell (CSC)-like subpopulation in neuroblastoma is known to be marked by expression...
20.
Richter M, Dayaram T, Gilmartin A, Ganji G, Pemmasani S, Van Der Key H, et al.
PLoS One
. 2015 Feb;
10(2):e0115635.
PMID: 25658463
The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins involved in DNA damage response including p53, CHK2, Histone H2AX, and ATM, and it has...