Jason Flannick
Overview
Explore the profile of Jason Flannick including associated specialties, affiliations and a list of published articles.
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80
Citations
13441
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Recent Articles
1.
Dilliott A, Costanzo M, Bandres-Ciga S, Blauwendraat C, Casey B, Hoang Q, et al.
Neurol Genet
. 2025 Feb;
11(2):e200246.
PMID: 39996130
Although large-scale genetic association studies have proven useful for the delineation of neurodegenerative disease processes, we still lack a full understanding of the pathologic mechanisms of these diseases, resulting in...
2.
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Su C, Chen Y, et al.
Nat Genet
. 2025 Jan;
57(2):345-357.
PMID: 39856218
Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins...
3.
Du X, Mendez-Lara K, Hu S, Diao R, Bhavimani G, Hernandez R, et al.
Diabetes
. 2025 Jan;
PMID: 39854214
PPARγ is the pharmacological target of thiazolidinediones (TZDs), potent insulin sensitizers that prevent metabolic disease morbidity but are accompanied by side effects such as weight gain, in part due to...
4.
DeForest N, Wang Y, Zhu Z, Dron J, Koesterer R, Natarajan P, et al.
Nat Commun
. 2024 Sep;
15(1):8068.
PMID: 39277575
Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological studies. To discover novel insulin resistance genes...
5.
Jurgens S, Wang X, Choi S, Weng L, Koyama S, Pirruccello J, et al.
Nat Genet
. 2024 Aug;
56(9):1811-1820.
PMID: 39210047
Large-scale sequencing has enabled unparalleled opportunities to investigate the role of rare coding variation in human phenotypic variability. Here, we present a pan-ancestry analysis of sequencing data from three large...
6.
Dilliott A, Costanzo M, Bandres-Ciga S, Blauwendraat C, Casey B, Hoang Q, et al.
medRxiv
. 2024 Jun;
PMID: 38853922
Although large-scale genetic association studies have proven useful for the delineation of neurodegenerative disease processes, we still lack a full understanding of the pathological mechanisms of these diseases, resulting in...
7.
Carvalho N, He Y, Smadbeck P, Flannick J, Mercader J, Udler M, et al.
medRxiv
. 2024 Feb;
PMID: 38352440
While genetic factors, behavior, and environmental exposures form a complex web of interrelated associations in type 2 diabetes (T2D), their interaction is poorly understood. Here, using data from ~500K participants...
8.
Kwak S, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, et al.
Nat Metab
. 2024 Jan;
6(2):226-237.
PMID: 38278947
The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily, producing a growing public health concern that disproportionately affects minority groups. The genetic basis of...
9.
Costanzo M, Roselli C, Brandes M, Duby M, Hoang Q, Jang D, et al.
Circ Genom Precis Med
. 2023 Oct;
16(6):e004181.
PMID: 37814896
No abstract available.
10.
DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, et al.
Cell Genom
. 2023 Jul;
3(7):100339.
PMID: 37492105
Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry...