Jason E Donald
Overview
Explore the profile of Jason E Donald including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
482
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Recent Articles
1.
Schramm C, Hannigan B, Donald J, Keasar C, Saven J, DeGrado W, et al.
Structure
. 2012 May;
20(5):924-35.
PMID: 22579257
The complex hydrophobic and hydrophilic milieus of membrane-associated proteins pose experimental and theoretical challenges to their understanding. Here, we produce a nonredundant database to compute knowledge-based asymmetric cross-membrane potentials from...
2.
Kulp D, Subramaniam S, Donald J, Hannigan B, Mueller B, Grigoryan G, et al.
J Comput Chem
. 2012 May;
33(20):1645-61.
PMID: 22565567
We present the Molecular Software Library (MSL), a C++ library for molecular modeling. MSL is a set of tools that supports a large variety of algorithms for the design, modeling,...
3.
Montero M, Gulzar N, Klaric K, Donald J, Lepik C, Wu S, et al.
J Virol
. 2012 Jan;
86(6):2930-41.
PMID: 22238313
Failure to elicit broadly neutralizing (bNt) antibodies (Abs) against the membrane-proximal external region of HIV-1 gp41 (MPER) reflects the difficulty of mimicking its neutralization-competent structure (NCS). Here, we analyzed MPER...
4.
Kim Y, Donald J, Grigoryan G, Leser G, Fadeev A, Lamb R, et al.
Proc Natl Acad Sci U S A
. 2011 Dec;
108(52):20992-7.
PMID: 22178759
During cell entry, enveloped viruses fuse their viral membrane with a cellular membrane in a process driven by energetically favorable, large-scale conformational rearrangements of their fusion proteins. Structures of the...
5.
Yoon H, Golla R, Lesuisse E, Pain J, Donald J, Lyver E, et al.
Biochem J
. 2011 Sep;
441(1):473-80.
PMID: 21936771
Frataxin is a conserved mitochondrial protein deficient in patients with Friedreich's ataxia. Frataxin has been implicated in control of iron homoeostasis and Fe-S cluster assembly. In yeast or human mitochondria,...
6.
Donald J, Zhang Y, Fiorin G, Carnevale V, Slochower D, Gai F, et al.
Proc Natl Acad Sci U S A
. 2011 Feb;
108(10):3958-63.
PMID: 21321234
Membrane fusion is required for diverse biological functions ranging from viral infection to neurotransmitter release. Fusogenic proteins increase the intrinsically slow rate of fusion by coupling energetically downhill conformational changes...
7.
Donald J, Kulp D, DeGrado W
Proteins
. 2011 Feb;
79(3):898-915.
PMID: 21287621
Salt bridges occur frequently in proteins, providing conformational specificity and contributing to molecular recognition and catalysis. We present a comprehensive analysis of these interactions in protein structures by surveying a...
8.
Donald J, Zhu H, Litvinov R, DeGrado W, Bennett J
J Biol Chem
. 2010 Oct;
285(49):38658-65.
PMID: 20929856
Protein-protein interfaces are usually large and complementary surfaces, but specific side chains, representing energetic "hot spots," often contribute disproportionately to binding free energy. We used a computational method, comprehensive interface...
9.
Bissonnette M, Donald J, DeGrado W, Jardetzky T, Lamb R
J Mol Biol
. 2009 Jan;
386(1):14-36.
PMID: 19121325
To enter cells, enveloped viruses use fusion-mediating glycoproteins to facilitate the merger of the viral and host cell membranes. These glycoproteins undergo large-scale irreversible refolding during membrane fusion. The paramyxovirus...
10.
Donald J, Shakhnovich E
Nucleic Acids Res
. 2008 Oct;
37(Database issue):D191-4.
PMID: 18927118
The specificity-determining residue database (SDR database) presents residue positions where mutations are predicted to have changed protein function in large protein families. Because the database pre-calculates predictions on existing protein...