Jason C Lambert
Overview
Explore the profile of Jason C Lambert including associated specialties, affiliations and a list of published articles.
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21
Citations
843
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Recent Articles
1.
Isaacs K, Wall J, Paul Friedman K, Franzosa J, Goeden H, Williams A, et al.
J Expo Sci Environ Epidemiol
. 2023 May;
34(1):136-147.
PMID: 37193773
Background: The number of chemicals present in the environment exceeds the capacity of government bodies to characterize risk. Therefore, data-informed and reproducible processes are needed for identifying chemicals for further...
2.
Lambert J
Toxics
. 2023 Jan;
11(1).
PMID: 36668763
For over a decade, New Approach Methodologies (NAMs) such as structure-activity/read-across, -omics technologies, and Adverse Outcome Pathway (AOP), have been considered within regulatory communities as alternative sources of chemical and...
3.
Lizarraga L, Suter G, Lambert J, Patlewicz G, Zhao J, Dean J, et al.
Regul Toxicol Pharmacol
. 2022 Nov;
137:105293.
PMID: 36414101
The assessment of human health hazards posed by chemicals traditionally relies on toxicity studies in experimental animals. However, most chemicals currently in commerce do not meet the minimum data requirements...
4.
Mumtaz M, Nickle R, Lambert J, Johnson M
Toxicol Sci
. 2021 Oct;
185(1):1-9.
PMID: 34718822
Federal statutes authorize several agencies to protect human populations from chemical emergencies and provide guidance to evacuate, clean, and reoccupy affected areas. Each of the authorized federal agencies has developed...
5.
Williams A, Lambert J, Thayer K, Dorne J
Environ Int
. 2021 May;
154:106566.
PMID: 33934018
For the past six decades, human health risk assessment of chemicals has relied on in vivo data from human epidemiological and experimental animal toxicological studies to inform the derivation of...
6.
Thomas R, Bahadori T, Buckley T, Cowden J, Deisenroth C, Dionisio K, et al.
Toxicol Sci
. 2019 Mar;
169(2):317-332.
PMID: 30835285
The U.S. Environmental Protection Agency (EPA) is faced with the challenge of efficiently and credibly evaluating chemical safety often with limited or no available toxicity data. The expanding number of...
7.
Lizarraga L, Dean J, Kaiser J, Wesselkamper S, Lambert J, Zhao Q
Regul Toxicol Pharmacol
. 2019 Feb;
103:301-313.
PMID: 30794837
Deriving human health risk estimates for environmental chemicals has traditionally relied on in vivo toxicity databases to characterize potential adverse health effects and associated dose-response relationships. In the absence of...
8.
Dean J, Zhao Q, Lambert J, Hawkins B, Thomas R, Wesselkamper S
Toxicol Sci
. 2017 Jan;
157(1):85-99.
PMID: 28123101
The rate of new chemical development in commerce combined with a paucity of toxicity data for legacy chemicals presents a unique challenge for human health risk assessment. There is a...
9.
Thomas R, Philbert M, Auerbach S, Wetmore B, Devito M, Cote I, et al.
Toxicol Sci
. 2013 Aug;
136(1):4-18.
PMID: 23958734
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into...
10.
Thomas R, Wesselkamper S, Wang N, Zhao Q, Petersen D, Lambert J, et al.
Toxicol Sci
. 2013 Apr;
134(1):180-94.
PMID: 23596260
The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development is overwhelming the capacity of the traditional risk assessment paradigm. More efficient approaches...