Jason C Lambert
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Explore the profile of Jason C Lambert including associated specialties, affiliations and a list of published articles.
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21
Citations
843
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Recent Articles
11.
Wang N, Zhao Q, Wesselkamper S, Lambert J, Petersen D, Hess-Wilson J
Regul Toxicol Pharmacol
. 2012 Feb;
63(1):10-9.
PMID: 22369873
Hazard identification and dose-response assessment for chemicals of concern found in various environmental media are typically based on epidemiological and/or animal toxicity data. However, human health risk assessments are often...
12.
Thomas R, Clewell 3rd H, Allen B, Wesselkamper S, Wang N, Lambert J, et al.
Toxicol Sci
. 2010 Nov;
120(1):194-205.
PMID: 21097997
The traditional approach for estimating noncancer and cancer reference values in quantitative chemical risk assessment is time and resource intensive. The extent and nature of the studies required under the...
13.
Lambert J, Lipscomb J
Regul Toxicol Pharmacol
. 2007 Sep;
49(3):183-94.
PMID: 17804132
It is inevitable that in a lifetime humans will be exposed to a diverse array of chemical mixtures through occupational, recreational, and/or domestic activities. These mixtures may be simple, consisting...
14.
Bergheim I, Guo L, Davis M, Lambert J, Beier J, Duveau I, et al.
Gastroenterology
. 2006 Jun;
130(7):2099-112.
PMID: 16762632
Background & Aims: The biguanide drug metformin has recently been found to improve steatosis and liver damage in animal models and in humans with nonalcoholic steatohepatitis. Methods: The aim of...
15.
Zhang X, Lambert J, Doll M, Walraven J, Arteel G, Hein D
J Pharmacol Exp Ther
. 2005 Sep;
316(1):289-94.
PMID: 16192314
4,4'-Methylenedianiline (MDA) is widely used in the manufacturing of polyurethane foam, epoxy resins, and polymers. Exposure to MDA induces liver damage in humans and rats. MDA undergoes N-acetylation catalyzed by...
16.
Lambert J, Zhou Z, Wang L, Song Z, McClain C, Kang Y
Am J Pathol
. 2004 May;
164(6):1959-66.
PMID: 15161632
Intestinal-derived endotoxins are importantly involved in alcohol-induced liver injury. Disruption of intestinal barrier function and endotoxemia are common features associated with liver inflammation and injury due to acute ethanol exposure....
17.
McKim S, Gabele E, Isayama F, Lambert J, Tucker L, Wheeler M, et al.
Gastroenterology
. 2004 Jan;
125(6):1834-44.
PMID: 14724835
Background & Aims: Oxidative stress contributes to early alcohol-induced liver injury, and superoxide (O(2)*-) production from NADPH oxidase plays a key role. However, the production of the free radical nitric...
18.
Zhou Z, Wang L, Song Z, Lambert J, McClain C, Kang Y
Am J Pathol
. 2003 Aug;
163(3):1137-46.
PMID: 12937155
Tumor necrosis factor-alpha (TNF-alpha) production is a critical factor in the pathogenesis of alcoholic liver injury. Both oxidative stress and endotoxin have been implicated in the process of alcohol-induced TNF-alpha...
19.
Lambert J, Zhou Z, Kang Y
Exp Biol Med (Maywood)
. 2003 Apr;
228(4):406-12.
PMID: 12671185
Apoptosis is critically involved in hepatic pathogenesis induced by acute alcohol exposure. This study was undertaken to test the hypothesis that zinc interferes with an important Fas ligand-mediated pathway in...
20.
Lambert J, Zhou Z, Wang L, Song Z, McClain C, Kang Y
J Pharmacol Exp Ther
. 2003 Mar;
305(3):880-6.
PMID: 12626662
Acute ethanol exposure causes liver injury in experimental animals, and accumulating evidence suggests that a major responsible factor for the pathogenesis is endotoxemia, which results from bacterial endotoxin leakage from...